3brd_A : 3D-footprint complex

structure name	CSL (LAG-1) BOUND TO DNA WITH LIN-12 RAM PEPTIDE, P212121 (LIN-12 AND GLP-1 PHENOTYPE PROTEIN 1, ISOFORM A)
reference	Wilson et al. J.Biol.Chem. 283 14781 2008
source	CAENORHABDITIS ELEGANS
experiment	X-ray (resolution=2.21, R-factor=0.211)
structural superfamily	DNA-binding protein LAG-1 CSL;p53-like transcription factors;E set domains;
sequence family	Betatrefoil; LAG1, DNA binding; IPT/TIG domain;
redundant complexes	1ttu_A 2fo1_A 3brf_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3brd_A interface=35,38,40,142,143,146,170,171, vqsltsdrmidflsnkekyecvisifhakvaqksYgnEkRffcpppciyligqgwklkkdrvaqlyktlqqatelvayigigsdtserqqldfpniydycaaktlyisdsdkrkyfdlnaqffygcgmeiggfvsqrikviSKpsKkktdckylciasgtkvalfnrlrSQtvstrylhvegnafhasstkwgaftihlfddqetdnfavrdgfvyygsvvklvdsvtgialprlrirkvdkqqvildascseepvsqlhkcafqmidnelvylclshdkiiqhqatainehrhqindgaawtiistdkaeyrffeamgqvanpispcpvvgslevdghgeasrvelhgrdfkpnlkvwfgatpvettfrseeslhcsippvsqvrneqthwmftnrttgdvevpislvrddgvvyssgltfsyksl
interface signature	YERSKKSQ

Estimated binding specificities ?

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# IC=4.085 IC/col=0.817 n_of_columns=5

specificity:

A |   9   0   9   0  69
C |   9   0   9   0   9
G |   9  96  69  96   9
T |  69   0   9   0   9

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Dendrogram of similar interfaces ?

matrix format

  
  YTETRG--STKGKT--STQA----   L                              +-3brd_A    
                                             +--------------1 
  YTECRG--STKG----STQG----   L   +-----------2              +-3iag_C    
                                 !           ! 
  YTECRG--STKG--RT--------   L --3           +----------------5e24_E    
                                 ! 
  ------KT------------KTRG   L   +----------------------------1nfk_A

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updated Fri Sep 13 16:55:07 2024