3f73_B : 3D-footprint complex

structure name	ALIGNMENT OF GUIDE-TARGET SEED DUPLEX WITHIN AN ARGONAUTE SILENCING COMPLEX (ARGONAUTE)
reference	Juranek et al. Nature 456 921 2008
source	THERMUS THERMOPHILUS
experiment	X-ray (resolution=3.00, R-factor=0.221)
structural superfamily	Ribonuclease H-like;
sequence family	Piwi domain 450;
multimeric complexes	3hk2_AB 3hvr_AB
reference complex	4n41_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3f73_B interface=45,48,49,79,214,215,223,249,251,252,263,274,406,407,409,412,428,430,439,440,443,600,632, lgktevflnrfalrplnpeelrpwrlevvldpppgreevypllaQvaRRaggvtvrmgdglaswsppevlvlegtlarMgqtyayrlypkgrrpldpkdpgersvlsalarrllqerlrrlegvwveglavyrrehargpgwrvlggavldlwvsdsgafllevdpayrilcemsleawlaqghplpkrvrnaydrrtwellrlgeedpkelpLPgglslldYhaskgrlqgreggrvawvadpkdprKpIPhltgllvpvlTledlhgslalSlpweerrrrtreiaswigrrlglgtpeavraqayrlsipklmgrravskpadalrvgfyraqetalallrldgaqgwpeflrrallrafgasgaslrlhtlhahpsqglafrealrkakeegvqavlvltpPMaWedRnrlkalllreglpsqIlNvplreeerHRweNallgllakaglqvvalsgypaelavgfdaggresfrfggaacavggghllwtlpeaqaipqevvwdlleetlwafrragrlpsrvlllrdgrvpqdefalalealaregiaydlvsvrksgggrvypvqgrladglyvpledktfllltvhrrgtpRplklvheagdtplealahqifhltrlypasgFafprlpaplhladrlvkevgrlgirhlkevdreklffv
interface signature	QRRMLPYKIPTSPMWRINHRNRF

Estimated binding specificities ?

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# IC=8.450 IC/col=0.563 n_of_columns=15

specificity:

A |   0   0  24  24  24  12  24  18  18  24  24   0  96   0   0
C |   0   0  24  24  24  18  24  18  12  24  24   0   0   0   0
G |   0  96  24  24  24  18  24  42  12  24  24   0   0  96   0
T |  96   0  24  24  24  48  24  18  54  24  24  96   0   0  96

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updated Sat Aug 2 03:49:43 2025