Estimated binding specificities ?

structure nameCRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE N478 MUTANT PROTEIN COMPLEXED WITH DNA GUIDE STRAND AND 19-NT RNA TARGET STRAND
(ARGONAUTE)
referencePatel et al. Nature 461 754 2009
sourceTHERMUS THERMOPHILUS
experimentX-ray (resolution=2.80, R-factor=0.207)
structural superfamilyRibonuclease H-like;
sequence familyPiwi domain 572;
multimeric complexes3hk2_AB 3hvr_AB
reference complex4n41_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
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# IC=4.166 IC/col=0.260 n_of_columns=16 specificity:   
A |   0   0  31  24  16  24  24  24  24  24  24  24  24  21  24   0
C |   0   0  21  24  16  24  24  24  24  24  24  24  24  23  24   0
G |   0  96  21  24  48  24  24  24  24  24  24  24  24  21  24   0
T |  96   0  23  24  16  24  24  24  24  24  24  24  24  31  24  96
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updated Sat Aug 2 03:58:39 2025