3ho1_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE N546 MUTANT PROTEIN COMPLEXED WITH DNA GUIDE STRAND AND 12-NT RNA TARGET STRAND (ARGONAUTE)
reference	Patel et al. Nature 461 754 2009
source	THERMUS THERMOPHILUS
experiment	X-ray (resolution=2.60, R-factor=?)
structural superfamily	Ribonuclease H-like;
sequence family	Piwi domain 534;
redundant complexes	3hm9 3hvr 3dlh 3hk2 3f73 3hxm 3hjf
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3ho1_A interface=219,242,244,257,403,405,408,424,426,435,436,439,536,603,635, nhlgktevflnrfalrplnpeelrpwrlevvldpppgreevypllaqvarraggvtvrmgdglaswsppevlvlegtlarmgqtyayrlypkgrrpldpkdpgersvlsalarrllqerlrrlegvwveglavyrrehargpgwrvlggavldlwvsdsgafllevdpayrilcemsleawlaqghplpkrvrnaydrrtwellrlgeedpkelslldYhaskgrlqgreggrvawvadpkKpIphltgllvpvltLedlheeegslalslpweerrrrtreiaswigrrlglgtpeavraqayrlsipklmgrravskpadalrvgfyraqetalallrldgaqgwpeflrrallrafgasgaslrlhtlhahpsqglafrealrkakeegvqavlvltppMaWedRnrlkalllreglpsqIlNvplreeerHRweNallgllakaglqvvalsgaypaelavgfdaggresfrfggaacavggghllwtlpeaqageripqevvwdlleetlwafrrkagrlpsrvlllrngRvpqdefalalealaregiaydlvsvrksgggrvypvqgrladglyvpledktfllltvhrdfrgtpRplklvheagdtplealahqifhltrlypasgFafprlpaplhladrlvkevgrlgirhlkevdreklffv
interface signature	YKILMWRINHRNRRF

Estimated binding specificities ?

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# IC=7.140 IC/col=0.476 n_of_columns=15

specificity:

A |   0   0  24  24  24  13  54   0  24  24  24  24  24   0   0
C |   0   0  24  24  24  13  13   0  24  24  24  24  24   0   0
G |   0  96  24  24  24  13  16  96  24  24  24  24  24  96   0
T |  96   0  24  24  24  57  13   0  24  24  24  24  24   0  96

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updated Mon Dec 16 20:59:16 2024