3lap_B : 3D-footprint complex

structure name	THE STRUCTURE OF THE INTERMEDIATE COMPLEX OF THE ARGININE REPRESSOR FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO ITS DNA OPERATOR AND L- CANAVANINE. (Arginine repressor)
reference	TB Structural Genomics Consortium (TBSGC)
source	Mycobacterium tuberculosis
experiment	X-ray (resolution=2.15, R-factor=0.185)
structural superfamily	C-terminal domain of arginine repressor;"Winged helix" DNA-binding domain;
sequence family	Arginine repressor, DNA binding domai; Arginine repressor, Cterminal domain;
multimeric complexes	3laj_AD 3laj_BF 3laj_CE 3lap_AD 3lap_BF 3lap_CE
redundant complexes	3laj_C
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3lap_B interface=37,38,39,42,43, anragrqarivailssaqvrsqnelaallaaegievTQAtlSRdleelgavklrgadggtgiyvvpegvsggtdrmarllgellvstddsgnlavlrtppgaahylasaidraalpqvvgtiagddtilvvarepttgaqlagmfenlr
interface signature	TQASR

Estimated binding specificities ?

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# IC=5.300 IC/col=0.883 n_of_columns=6

specificity:

A |  11  96  11   0   0  67
C |   9   0   9   0  96  11
G |   9   0   9  96   0   9
T |  67   0  67   0   0   9

scan!

Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: ArgR
GTTTGC	PubMed	3lap_B(6.54e-03), 3laj_C(6.56e-03), 3ere_D(6.52e-03)
CATGAATAAAAATG	PubMed	3lap_B(1.77e-03), 3fhz_AD(9.57e-03), 3fhz_BF(2.32e-04), ... (total=11)

Dendrogram of similar interfaces ?

matrix format

  
  DTRGRCTTKT----------RT--   L     +-----------------------------2o9l_A    
                                   ! 
  --------YG--------------       +-3                            +4lb5_B    
                                 ! !             +--------------1 
  TT--KATGLTRT------KA--FT   L   ! +-------------2              +2p7c_B    
                               --4               ! 
  ----------YGRG----------       !               +---------------4wcg_A    
                                 ! 
  --RCET--SA----QAKG------   L   +-----------------------------5lxu_A

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updated Tue Dec 19 07:48:45 2023