| structure name | EGR1/ZIF268 ZINC FINGERS IN COMPLEX WITH METHYLATED DNA (Early growth response protein 1) |
| reference | Olanrewaju et al. 'Genes 28 2304 2014 |
| source | Homo sapiens |
| experiment | X-ray (resolution=1.59, R-factor=0.140) |
| structural superfamily | beta-beta-alpha zinc fingers; |
| sequence family | Zinc finger, C2H2 type; |
| multimeric complexes | 1p47_AB |
| redundant complexes | 1zaa 4x9j 1jk1 1a1l 1a1i 1a1j 1a1f 1jk2 1a1h 1a1g 1a1k 1p47 4r2d 1aay 4r2c |
| reference complex | 4x9j_A |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | RDERRDHTRDER |
Estimated binding specificities ?
| readout + contact |  |
A | 0 0 0 16 0 0 0 24 16 C | 0 80 0 0 0 0 0 24 16 G | 96 0 96 0 96 96 96 24 48 T | 0 16 0 80 0 0 0 24 16scan! |
Related DNA sequences reported in the literature ?
| site | source | matches (E-value) |
|---|---|---|
| term: ZIF268 | ||
| AGCGTGGGCGT | PubMed | 4r2a_A(3.37e-13), 1p47_AB(1.90e-12), 1zaa_C(2.84e-13), ... (total=15) |
| GCGTGGGCG | PubMed | 4r2a_A(1.55e-15), 1p47_AB(2.72e-12), 1zaa_C(1.22e-15), ... (total=16) |
| GCGTGGGGCG | PubMed | 4r2a_A(5.33e-07), 1p47_AB(1.50e-05), 1zaa_C(6.09e-07), ... (total=16) |
| GGGCGG | PubMed | 4r2a_A(9.78e-05), 1p47_AB(6.25e-07), 1zaa_C(8.73e-05), ... (total=12) |
Dendrogram of similar interfaces ?
matrix format----KG--WTKA--------HCHG--RGTA--ACNA--KGRG L +-------------1tf6_A +--------------6 ----RGSTDTEGRG--RGSGDCHG--TTRG--DAEG--RG-- ! +-------------4x9j_A ! ----QA--TCNA----QAHTTT----QATTLAHGTCDTRG-- L ! +1g2d_F ! +--------------1 ----RGSTDAQGRG--RG--DCHG--TTRG--DAEC--RG-- L ! +----7 +4r2q_A ! ! ! ------------KT--EC--SCKG--RGLT--FCNA------ L ! ! +--------------1ubd_C ! +-9 ----RA----NC------ATSGDC--KGDCPTSGSARTKG-- L ! ! ! +------------------2gli_A ! ! ! ! --------TTSGRG--LT--ETYC----NTYGQG-------- L ! ! ! ! +4f6m_A -14 ! +-8 +--------2 ----QA--SGNAKG--QASTSCDC--KGRG--DCHA--RG-- L ! ! ! +--4 +1mey_C ! +--10 ! ! ! PCYCRG--DA--RG--RG--DCHG----RG--DCEC--RG-- L ! ! ! +------5 +--------2prt_A ! ! ! ! ----RG--DCECRG--RG--DCHG------------------ L ! ! ! ! +------1f2i_J ! +-11 ! +----3 --------------RGST--YGYC----QC--TGSTRGYT-- L ! ! ! ! +------4is1_C ! ! ! ! ----QA--TTNA--STQAQTATSTNTATTTLAHGTC--RG-- L ! +-12 ! +---------------------1g2f_F ! ! ! ! --------KGDCRG--QARGATNA----QA--ATHG------ L ! ! ! +-------------------------2i13_A +-13 ! ----------------HTITSTNACTRGRG--DCNA------ L ! +---------------------------2drp_D ! ----------------RG--DGEC--RGRGSGDCHA------ L +----------------------------2wbs_A |
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updated Thu Sep 12 20:01:38 2024