structure nameHUMAN HSF2 DNA-BINDING DOMAIN BOUND TO 2-SITE HSE DNA AT 1.73 ANGSTROMS RESOLUTION
(Heat shock factor protein 2)
referenceJaeger et al. Nat.Struct.Mol.Biol. 23 147 2016
sourceHomo sapiens
experimentX-ray (resolution=1.73, R-factor=0.153)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyHSFtype DNAbinding;
multimeric complexes5d8l_DF 7dcu_ABC
redundant complexes5d8l
reference complex7dci_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKSRQMR

Estimated binding specificities ?

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# IC=3.142 IC/col=0.786 n_of_columns=4 specificity:   
A |  13   0   0  13
C |  13   0   0  54
G |  57   0   0  13
T |  13  96  96  16
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----------------STRTQTMT--------RG   L                            +5d8k_B    
                                                        +-----------2 
  ----KTHG--------------------------                    !           +5hdn_C    
                                                        !  
  ----------------STRTQTMT----------                    !          +--3hts_B    
                                                        !        +-6 
  ----------------KTRGYA------------   L   +-----------11        ! ! +4l18_B    
                                           !            !        ! +-4 
  ----------------KTRGYA------------   L   !            !  +-----7   +3wts_C    
                                           !            !  !     ! 
  --------------DCKTRGYA------------   L   !            !  !     !  +5ybd_A    
                                           !            !  !     +--3 
  --------------DCKTRGYA--KA--------   L   !            +-10        +5jvt_A    
                                           !               !  
  ----------------KTRGYA------------   L -12               !         +1bc8_C    
                                           !               !   +-----1 
  ----------------KTRGYA------------   L   !               +---8     +1hbx_G    
                                           !                   ! 
  --------------EC--RGYC------------   L   !                   +-----2stw_A    
                                           !  
  --TT--------KATTTGLTRT--KA--FTYT--   L   !                  +------2p7c_B    
                                           +------------------9 
  ------------------YG--------------                          !    +-4lb5_B    
                                                              +----5 
  YC------STQT--YTPT--------LG------   L                           +-5x11_A    
                                         

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updated Thu Sep 12 21:05:03 2024