interface graph thumbnail
legend  pdf

structure nameTDG ENZYME-SUBSTRATE COMPLEX
(GT mismatch-specific thymine DNA glycosylase)
referencePozharski et al. 'Nucleic 44 10248 2016
sourceHomo sapiens
experimentX-ray (resolution=1.54, R-factor=0.187)
structural superfamilyUracil-DNA glycosylase-like;
sequence familyUracil DNA glycosylase superfamily;
multimeric complexes2rba_AB 3uo7_AB 3uob_AB
redundant complexes6u16 6u15 5ff8 5t2w 6u17
reference complex4z47_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureHSKARCAQ

Estimated binding specificities ?

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# IC=2.655 IC/col=0.664 n_of_columns=4 specificity:   
A |  74   0   7  49
C |   7   0   7  17
G |   7  96   8  15
T |   8   0  74  15
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --RA--RCQTNTTC----   L            +-----------2dp6_A    
                              +-----1 
  ------------RG----       +--2     +-----------6iod_A    
                           !  ! 
  KT--TT--------RA--     --3  +-----------------4yig_E    
                           ! 
  ------PG--------NG       +--------------------1oe4_B

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updated Sat Aug 2 08:50:36 2025