5iy8_ABEMNPTV : 3D-footprint complex

structure name	HUMAN HOLO-PIC IN THE INITIAL TRANSCRIBING STATE
source	HOMO SAPIENS
experiment	NMR
structural superfamily	Cyclin-like;Zinc beta-ribbon;Transcription factor IIA TFIIA, beta-barrel domain;Transcription factor IIA TFIIA, alpha-helical domain;TATA-box binding protein-like;Rap30/74 interaction domains;"Winged helix" DNA-binding domain;P-loop containing nucleoside triphosphate hydrolases;
reference complex	5iy6_M 5iy6_N 5iy6_P 5iy6_T 5iy6_V
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5iy8_A interface=235,300,823,1385, dsacplrtikrvqfgvlspdelkrmsvteggikypetteggrpklgglmdprqgviertgrcqtcagnmtecpghfghielakpvfhvgflvktmkvlrcvcffcskllvdsnnpkikdilakskgqpkkrlthvydlckgkniceggghggcgryqprirrsglelyaewkhvnedsqekkillspervheifkrisdeecfvlgmepryarpewmivtvlpvpplsvrpavvMqgsarnqddlthkladivkinnqlrrneqngaaahviaedvkllqfhvatmvdnelpglpramqKsgrplkslkqrlkgkegrvrgnlmgkrvdfsartvitpdpnlsidqvgvprsiaanmtfaeivtpfnidrlqelvrrgnsqypgakyiirdngdridlrfhpkpsdlhlqtgykverhmcdgdivifnrqptlhkmsmmghrvrilpwstfrlnlsvttpynadfdgdemnlhlpqsletraeiqelamvprmivtpqsnrpvmgivqdtltavrkftkrdvflergevmnllmflstwdgkvpqpailkprplwtgkqifsliipghincirthsthpddedsgpykhispgdtkvvvengelimgilckkslgtsagslvhisylemghditrlfysniqtvinnwllieghtigigdsiadsktyqdiqntikkakqdvieviekahnneleptpgntlrqtfenqvnrilndardktgssaqkslseynnfksmvvsgakgskinisqviavvgqqnvegkripfgfkhrtlphfikddygpesrgfvensylagltptefffhamggreglidtavkTaetgyiqrrliksmesvmvkydatvrnsinqvvqlrygedglagesvefqnlatlkpsnkafekkfrfdytneralrrtlqedlvkdvlsnahiqnelerefermredrevlrvifptgdskvvlpcnllrmiwnaqkifhinprlpsdlhpikvvegvkelskklvivngddplsrqaqenatllfnihlrstlcsrrmaeefrlsgeafdwllgeieskfnqaiahpgemvgalaaqslgepatqmtlntfhyagvsaknvtlgvprlkeliniskkpktpsltvfllgqsardaerakdilcrlehttlrkvtantaiyydpnpqstvvaedqewvnvyyempdfdvarispwllrveldrkhmtdrkltmeqiaekinagfgddlncifnddnaeklvlririmnsdenkmqeeeevvdkmdddvflrciesnmltdmtlqgieqiskvymhlpqtdnkkkiiitedgefkalqewiletdgvslmrvlsekdvdpvrttsndiveiftvlgieavrkalerelyhvisfdgsyvnyrhlallcdtmtcrghlmaitRhgvnrqdtgplmkcsfeetvdvlmeaaahgesdpmkgvsenimlgqlapagtgcfdllldaekckygme > 5iy8_B interface=227,253,325,329,404,449,452,480,485,1071, ydedddeitpdlwqeacwivissyfdekglvrqqldsfdefiqmsvqrivedappidlqaeaqhasgeveeppryllkfeqiylskpthwerdgapspmmpnearlrnltysaplyvditktvikegeeqlqtqhqktfigkipimlrstycllngltdrdlcelnecpldpggyfiingsekvliaqekmatntvyvfakkdskyaytgecrsclenssrptstiWvsmlarggqgakksaigqrivatlpYikqevpiiivfralgfvsdrdilehiiydfedpemmemvkpsldeafviqeqnvalnfigsrgakpgvtkeKrikYakevlqkemlphvgvsdfcetkkayflgymvhrlllaalgrrelddrdhygnkrldlagpllaflfrgmfknllKevriyaqkfidrgkdfnlelaiktriisdglkyslatgnwgdqkKahQaragvsqvlnrltfastlshlrrlnspIgrdgKlakprqlhntlwgmvcpaetpeghavglvknlalmayisvgsqpspilefleewsmenleeispaaiadatkifvngcwvgihkdpeqlmntlrklrrqmdiivsevsmirdirereiriytdagricrpllivekqklllkkrhidqlkereynnyswqdlvasgvveyidtleeetvmlamtpddlqekevaycstythceihpsmilgvcasiipfpdhnqsprntyqsamgkqamgvyitnfhvrmdtlahvlyypqkplvttrsmeylrfrelpaginsivaiasytgynqedsvimnrsavdrgffrsvfyrsykeqeskkgfdqeevfekptretcqgmrhaiydkldddgliapgvrvsgddviigktvtlpenedelestnrrytkrdcstflrtsetgivdqvmvtlnqegykfckirvrsvripqigdkfasrhgqkgtcgiqyrqedmpftcegitpdiiinphaipsrmtighlieclqgkvsankgeigdatpfndavnvqkisnllsdygyhlrgnevlyngftgrkitsqifigptyyqrlkhmvddkihsrargpiqilnrqpmegrsRdgglrfgemerdcqiahgaaqflrerlfeasdpyqvhvcnlcgimaiantrthtyecrgcrnktqislvrmpyackllfqelmsmsiaprmmsv > 5iy8_E interface= mddeeetyrlwkirktimqlchdrgylvtqdeldqtleefkaqsgdkpsegrprrtdltvlvahnddptdqmfvffpeepkvgiktikvycqrmqeenitralivvqqgmtpsakqslvdmapkyileqflqqellinitehelvpehvvmtkeevtellaryklrenqlpriqagdpvaryfgikrgqvvkiirpsetagryityrlvq > 5iy8_M interface=47,49,50,51,54,64,66,80,97,99,100,106,110,113, ldalprvtcpnhpdailvedyragdmicpecglvvgdrvidvgsewRtFSNdkAtkdpsrvgdSqNpllsdgdlstmigKgtgaasfdefgnskyqNrRTmsssdRammNafKeittmadrinlprnivdrtnnlfkqvyeqkslkgrandaiasaclyiacrqegvprtfkeicavsriskkeigrcfklilkaletsvdlittgdfmsrfcsnlclpkqvqmaathiarkaveldlvpgrspisvaaaaiymasqasaekrtqkeigdiagvadvtirqsyrliyprapdlfptdfkfdtpvdklpql > 5iy8_N interface= tvpklyrsviedvindvrdiflddgvdeqvlmelktlwenklmgqvEeEPLnsEddvsdeegqElFdtenvvvcqydkiHrsknkwkfhlkdgimnLnGRdyifsKaigDaeW > 5iy8_P interface=15,17,45,60,62,68,70,105,136,137,151,153,159,161, tpasessgivpqlqNiVstvnlgckldlktialrarnaeynpkrFaavimrireprttaLiFssgkmVcTgakseeqsrlaarkyarvvqklgfpakfldfkiqNmvgscdvkfpirleglvlthqqfssyepelFPgliyrmikprivlLiFvsgkvVlTgakvraeiyeafeniypilkgfrk > 5iy8_T interface=158,212,213, aergeldltgakqntgvwlvkvpkylsqqwakasgrgevgklriaktqgrtevsftlnedlanehpfvlqsvggqtltvftesssdklslegivvqraecrpaasenymrlkrlqieesskpvrlsqqldkvvttnykpvanhqynieyerkkkedgKraradkqhvldmlfsafekhqyynlkdlvditkqpvvylkeilkeigvqnvkgIHkntwelkpe > 5iy8_V interface=170, ipmdlfdfyeqmdkdeeeeeetqtvsfevkqemieelqkrcihleypllaeydfrndsvnpdinidlkptavlrpyqekslrkmfgngrarsgvivlpcgagkslvgvtaactvrkrclvlgnsavsveqwkaqfkmwstiddsqicrftsdakdkpigcsvaistysmLghttkrsweaervmewlktqewglmildevhtipakmfrrvltivqahcklgltatlvreddkivdlnfligpklyeanwmelqnngyiakvqcaevwcpmspefyreyvaiktkkrillytmnpnkfracqflikfherrndkiivfadnvfalkeyairlnkpyiygptsqgermqilqnfkhnpkintifiskvgdtsfdlpeanvliqisshggsrrqeaqrlgrvlrakkgmvaeeynaffyslvsqdtqemaystkrqrflvdqgysfkvitklagmeeedlafstkeeqqqllqkvla
interface signature	MKTR/WYKYKKQIKR//RFSNASNKNRTRNK/EEPLEEFHLGRKDW/NVFLFVTNFPLFVT/KIH/L

Estimated binding specificities ?

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# IC=34.957 IC/col=0.573 n_of_columns=61

specificity:

A |   7  96   0  96  96  96  96   0  24  24  24  24  24  24  24  24   0   0   6   0   0   0   0   0   8   6   0  24   2   0   2   2   2   0   2  24   0   0  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  80   2
C |   6   0   0   0   0   0   0   0  24  24  24  24  24  24  24  24   0   0  79   0   0   0   0   0   8   6   0  24   2   0   2   1   3   0   2  24   0   0  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   4  89
G |   4   0   0   0   0   0   0  96  24  24  24  24  24  24  24  24  96  96   4  96   0   0   0   0  12   6   0  24   2   0   3   0   2   0   3  24   0   0  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   6   2
T |  79   0  96   0   0   0   0   0  24  24  24  24  24  24  24  24   0   0   7   0  96  96  96  96  68  78  96  24  90  96  89  93  89  96  89  24  96  96  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   6   3

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updated Mon Jan 5 18:00:06 2026