structure nameHUMAN HOLO-PIC IN THE INITIAL TRANSCRIBING STATE
sourceHOMO SAPIENS
experimentNMR
structural superfamilyCyclin-like;Zinc beta-ribbon;Transcription factor IIA TFIIA, beta-barrel domain;Transcription factor IIA TFIIA, alpha-helical domain;TATA-box binding protein-like;Rap30/74 interaction domains;"Winged helix" DNA-binding domain;P-loop containing nucleoside triphosphate hydrolases;
reference complex5iy6_M 5iy6_N 5iy6_P 5iy6_T 5iy6_V
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureMKTR/WYKYKKQIKR//RFSNASNKNRTRNK/EEPLEEFHLGRKDW/NVFLFVTNFPLFVT/KIH/L

Estimated binding specificities ?

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# IC=34.857 IC/col=0.571 n_of_columns=61 specificity:   
A |   6  96   0  96  96  96  96   0  24  24  24  24  24  24  24  24   0   0   6   0   0   0   0   0  11   8   0  24   3   0   2   2   2   0   2  24   0   0  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  80   3
C |   8   0   0   0   0   0   0   0  24  24  24  24  24  24  24  24   0   0  78   0   0   0   0   0   8   4   0  24   2   0   3   0   3   0   2  24   0   0  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   4  89
G |   4   0   0   0   0   0   0  96  24  24  24  24  24  24  24  24  96  96   6  96   0   0   0   0  10   6   0  24   2   0   2   1   2   0   3  24   0   0  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   8   2
T |  78   0  96   0   0   0   0   0  24  24  24  24  24  24  24  24   0   0   6   0  96  96  96  96  67  78  96  24  89  96  89  93  89  96  89  24  96  96  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   4   2
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updated Wed Jul 30 08:53:52 2025