structure nameHUMAN HOLO-PIC IN THE INITIAL TRANSCRIBING STATE
sourceHOMO SAPIENS
experimentNMR
structural superfamilyCyclin-like;Zinc beta-ribbon;Transcription factor IIA TFIIA, beta-barrel domain;Transcription factor IIA TFIIA, alpha-helical domain;TATA-box binding protein-like;Rap30/74 interaction domains;"Winged helix" DNA-binding domain;P-loop containing nucleoside triphosphate hydrolases;
reference complex5iy6_M 5iy6_N 5iy6_P 5iy6_T 5iy6_V
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureMKTR/WYKYKKQIKR//RFSNASNKNRTRNK/EEPLEEFHLGRKDW/NVFLFVTNFPLFVT/KIH/L

Estimated binding specificities ?

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# IC=36.018 IC/col=0.590 n_of_columns=61 specificity:   
A |   1   5  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  11   0   0  24   1  96   1   0   4  96   0  24  96   5   7  96  96   0   0   0   6   0   0  24  24  24  24  24  24  24  24   0   0   3   0   0  96   0  82
C |   4   3  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   7  96   0  24   4   0  93   0   1   0   0  24   0  74   9   0   0  96   0  96   3  96  96  24  24  24  24  24  24  24  24  96   0   8  96   0   0   0   1
G |  90   8  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   7   0  96  24  90   0   1   0  90   0  96  24   0   8  69   0   0   0  96   0  86   0   0  24  24  24  24  24  24  24  24   0   0   1   0   0   0   0   6
T |   1  80  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  71   0   0  24   1   0   1  96   1   0   0  24   0   9  11   0   0   0   0   0   1   0   0  24  24  24  24  24  24  24  24   0  96  84   0  96   0  96   7
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updated Thu Jun 25 05:23:08 2026