5iy9_ABEMNPTV : 3D-footprint complex

structure name	HUMAN HOLO-PIC IN THE INITIAL TRANSCRIBING STATE (NO IIS)
source	HOMO SAPIENS
experiment	NMR
structural superfamily	Cyclin-like;Zinc beta-ribbon;Transcription factor IIA TFIIA, beta-barrel domain;Transcription factor IIA TFIIA, alpha-helical domain;TATA-box binding protein-like;Rap30/74 interaction domains;"Winged helix" DNA-binding domain;P-loop containing nucleoside triphosphate hydrolases;
reference complex	5iy6_M 5iy6_N 5iy6_P 5iy6_T 5iy6_V
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5iy9_A interface=240,823,824,1385,1386, dsacplrtikrvqfgvlspdelkrmsvteggikypetteggrpklgglmdprqgviertgrcqtcagnmtecpghfghielakpvfhvgflvktmkvlrcvcffcskllvdsnnpkikdilakskgqpkkrlthvydlckgkniceggghggcgryqprirrsglelyaewkhvnedsqekkillspervheifkrisdeecfvlgmepryarpewmivtvlpvpplsvrpavvmqgsaRnqddlthkladivkinnqlrrneqngaaahviaedvkllqfhvatmvdnelpglpramqksgrplkslkqrlkgkegrvrgnlmgkrvdfsartvitpdpnlsidqvgvprsiaanmtfaeivtpfnidrlqelvrrgnsqypgakyiirdngdridlrfhpkpsdlhlqtgykverhmcdgdivifnrqptlhkmsmmghrvrilpwstfrlnlsvttpynadfdgdemnlhlpqsletraeiqelamvprmivtpqsnrpvmgivqdtltavrkftkrdvflergevmnllmflstwdgkvpqpailkprplwtgkqifsliipghincirthsthpddedsgpykhispgdtkvvvengelimgilckkslgtsagslvhisylemghditrlfysniqtvinnwllieghtigigdsiadsktyqdiqntikkakqdvieviekahnneleptpgntlrqtfenqvnrilndardktgssaqkslseynnfksmvvsgakgskinisqviavvgqqnvegkripfgfkhrtlphfikddygpesrgfvensylagltptefffhamggreglidtavkTAetgyiqrrliksmesvmvkydatvrnsinqvvqlrygedglagesvefqnlatlkpsnkafekkfrfdytneralrrtlqedlvkdvlsnahiqnelerefermredrevlrvifptgdskvvlpcnllrmiwnaqkifhinprlpsdlhpikvvegvkelskklvivngddplsrqaqenatllfnihlrstlcsrrmaeefrlsgeafdwllgeieskfnqaiahpgemvgalaaqslgepatqmtlntfhyagvsaknvtlgvprlkeliniskkpktpsltvfllgqsardaerakdilcrlehttlrkvtantaiyydpnpqstvvaedqewvnvyyempdfdvarispwllrveldrkhmtdrkltmeqiaekinagfgddlncifnddnaeklvlririmnsdenkmqeeeevvdkmdddvflrciesnmltdmtlqgieqiskvymhlpqtdnkkkiiitedgefkalqewiletdgvslmrvlsekdvdpvrttsndiveiftvlgieavrkalerelyhvisfdgsyvnyrhlallcdtmtcrghlmaitRHgvnrqdtgplmkcsfeetvdvlmeaaahgesdpmkgvsenimlgqlapagtgcfdllldaekckygme > 5iy9_B interface=202,253,407,449,452,480,485,509,806, ydedddeitpdlwqeacwivissyfdekglvrqqldsfdefiqmsvqrivedappidlqaeaqhasgeveeppryllkfeqiylskpthwerdgapspmmpnearlrnltysaplyvditktvikegeeqlqtqhqktfigkipimlrstycllngltdrdlcelnecpldpggyfiingsekvliaqekmatntvyvfakKdskyaytgecrsclenssrptstiwvsmlarggqgakksaigqrivatlpYikqevpiiivfralgfvsdrdilehiiydfedpemmemvkpsldeafviqeqnvalnfigsrgakpgvtkekrikyakevlqkemlphvgvsdfcetkkayflgymvhrlllaalgrrelddrdhygnkrldlagpllaflfrgmfknllkevRiyaqkfidrgkdfnlelaiktriisdglkyslatgnwgdqkKahQaragvsqvlnrltfastlshlrrlnspIgrdgKlakprqlhntlwgmvcpaetpegHavglvknlalmayisvgsqpspilefleewsmenleeispaaiadatkifvngcwvgihkdpeqlmntlrklrrqmdiivsevsmirdirereiriytdagricrpllivekqklllkkrhidqlkereynnyswqdlvasgvveyidtleeetvmlamtpddlqekevaycstythceihpsmilgvcasiipfpdhnqsprntyqsamgkqamgvyitnfhvrmdtlahvlyypqkplvttrsmeylrfrelpaginsivaiasytgynqedsvimnrsavdrgffrsvfyrsyKeqeskkgfdqeevfekptretcqgmrhaiydkldddgliapgvrvsgddviigktvtlpenedelestnrrytkrdcstflrtsetgivdqvmvtlnqegykfckirvrsvripqigdkfasrhgqkgtcgiqyrqedmpftcegitpdiiinphaipsrmtighlieclqgkvsankgeigdatpfndavnvqkisnllsdygyhlrgnevlyngftgrkitsqifigptyyqrlkhmvddkihsrargpiqilnrqpmegrsrdgglrfgemerdcqiahgaaqflrerlfeasdpyqvhvcnlcgimaiantrthtyecrgcrnktqislvrmpyackllfqelmsmsiaprmmsv > 5iy9_E interface= mddeeetyrlwkirktimqlchdrgylvtqdeldqtleefkaqsgdkpsegrprrtdltvlvahnddptdqmfvffpeepkvgiktikvycqrmqeenitralivvqqgmtpsakqslvdmapkyileqflqqellinitehelvpehvvmtkeevtellaryklrenqlpriqagdpvaryfgikrgqvvkiirpsetagRyityrlvq > 5iy9_M interface=47,49,51,54,55,66,100,103,106,110,113, ldalprvtcpnhpdailvedyragdmicpecglvvgdrvidvgsewRtFsNdkATkdpsrvgdsqNpllsdgdlstmigkgtgaasfdefgnskyqnrrTmsSsdRammNafKeittmadrinlprnivdrtnnlfkqvyeqkslkgrandaiasaclyiacrqegvprtfkeicavsriskkeigrcfklilkaletsvdlittgdfmsrfcsnlclpkqvqmaathiarkaveldlvpgrspisvaaaaiymasqasaekrtqkeigdiagvadvtirqsyrliyprapdlfptdfkfdtpvdklpql > 5iy9_N interface= tvpklyrsviedvindvrdiflddgvdeqvlmelktlwenklmgqvEeEpLnsEDdvsdeegqelFdtenvvvcqydkihrsknkwkfhlkdgimnlngRdyIfsKaigDaeW > 5iy9_P interface=15,17,45,60,62,68,105,107,136,137,151,153,159,161, tpasessgivpqlqNiVstvnlgckldlktialrarnaeynpkrFaavimrireprttaLiFssgkmVctgakseeqsrlaarkyarvvqklgfpakfldfkiqNmVgscdvkfpirleglvlthqqfssyepelFPgliyrmikprivlLiFvsgkvVlTgakvraeiyeafeniypilkgfrk > 5iy9_T interface=158,212,213, aergeldltgakqntgvwlvkvpkylsqqwakasgrgevgklriaktqgrtevsftlnedlanehpfvlqsvggqtltvftesssdklslegivvqraecrpaasenymrlkrlqieesskpvrlsqqldkvvttnykpvanhqynieyerkkkedgKraradkqhvldmlfsafekhqyynlkdlvditkqpvvylkeilkeigvqnvkgIHkntwelkpe > 5iy9_V interface=170, ipmdlfdfyeqmdkdeeeeeetqtvsfevkqemieelqkrcihleypllaeydfrndsvnpdinidlkptavlrpyqekslrkmfgngrarsgvivlpcgagkslvgvtaactvrkrclvlgnsavsveqwkaqfkmwstiddsqicrftsdakdkpigcsvaistysmLghttkrsweaervmewlktqewglmildevhtipakmfrrvltivqahcklgltatlvreddkivdlnfligpklyeanwmelqnngyiakvqcaevwcpmspefyreyvaiktkkrillytmnpnkfracqflikfherrndkiivfadnvfalkeyairlnkpyiygptsqgermqilqnfkhnpkintifiskvgdtsfdlpeanvliqisshggsrrqeaqrlgrvlrakkgmvaeeynaffyslvsqdtqemaystkrqrflvdqgysfkvitklagmeeedlafstkeeqqqllqkvla
interface signature	RTARH/KYRKQIKHK/R/RFNATNTSRNK/EELEDFRIKDW/NVFLFVNVFPLFVT/KIH/L

Estimated binding specificities ?

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# IC=33.544 IC/col=0.541 n_of_columns=62

specificity:

A |   0  96   1  96  96  89  89   3   6  24  24  24  24  24  24  24   3   0   0  24   0   0   0   0  24   3   6  24   0   0   0  24   2   6   0  24   0   0   0  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  77   2
C |   2   0   2   0   0   2   2   2   5  24  24  24  24  24  24  24   2   0  96  24   0   0   0   0  24   2   6  24   0   0   0  24   3   6   0  24   0   0   0  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   5  90
G |   3   0   0   0   0   2   3  89  79  24  24  24  24  24  24  24  89  96   0  24   0   0   0   0  24   2   6  24   0   0   0  24   2   6   0  24   0   0   0  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   6   2
T |  91   0  93   0   0   3   2   2   6  24  24  24  24  24  24  24   2   0   0  24  96  96  96  96  24  89  78  24  96  96  96  24  89  78  96  24  96  96  96  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   8   2

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updated Mon Jan 5 18:07:05 2026