| structure name | HOMEOBOX TRANSCRIPTION FACTOR CDX2 BOUND TO METHYLATED DNA (Homeobox protein CDX-2) |
| reference | Morgunova et al. Science 356 ? 2017 |
| source | Homo sapiens |
| experiment | X-ray (resolution=2.66, R-factor=0.204) |
| structural superfamily | Homeodomain-like; |
| sequence family | Homeobox domain; |
| reference complex | 6es3_K |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | YRIQN |
Estimated binding specificities ?
| contact |  |
A | 13 24 24 0 96 96 54 C | 16 24 24 0 0 0 13 G | 13 24 24 0 0 0 16 T | 54 24 24 96 0 0 13scan! |
Related DNA sequences reported in the literature ?
| site | source | matches (E-value) |
|---|---|---|
| term: CDX2 | ||
| TATAAAA | PubMed | 5lty_K(1.05e-02) |
| TTTTAGG | PubMed | 5lty_K(1.05e-02) |
| GTTTAGA | PubMed | 5lty_K(1.05e-02) |
| GTTTATG | PubMed | 5lty_K(1.05e-02) |
Dendrogram of similar interfaces ?
matrix format----YARA----------IAQTNA-------- L +5lux_L +--12 RA----RA----------IAQTNAMC------ L ! +1puf_A ! RA----RT----------IAQTNA------KT L ! +4rdu_A ! +-1 --KG--RC----------IAQCNAYA------ L ! +-10 +1nk3_P ! ! ! ------RT----------NT--NAIARG---- L +-17 ! +1puf_B ! ! ! ------RT----------VAQTNA-------- L ! ! +-15 +5hod_A ! ! ! ! +-8 RA----RT----------VA--NAQT------ L ! ! ! ! ! +3d1n_M ! ! ! +-14 RT----RT----------VAQTNA-------- L ! ! ! ! +1fjl_B ! ! ! ! +-2 RA----RT----------VASGNA-------- L ! +-16 +-3 +3cmy_A ! ! ! ------RT----------IAQCNAMG------ L ! ! +1b72_A +-18 ! ------RT------------KGNA-------- L ! ! ! +2hos_A ! ! ! +-5 ------RA--------RCVTCTNAQTRC---- L ! ! ! ! +1au7_A ! ! +-11 ------RT----------IAKGNA-------- L ! ! ! +2hdd_A ! ! ! +-4 --------HTRT------NCSTNARG------ L +-19 ! +-9 +1k61_B ! ! ! ! --------RT--------NT--NAIARG---- L ! ! ! +4cyc_B ! ! ! ----------------RTVAIANAMCRG---- L ! ! ! +1le8_A ! ! +-----6 ------RT----------VASCNAQA------ L +-------20 ! +1gt0_C ! ! ! RT--RT--------VTKTIAQTNA-------- L ! ! +-------2me6_A ! ! ------RA----RCET--SAQAKG-------- L ! ! +-5lxu_A +--------21 +------13 ------RT----STVCKGDCRG---------- L ! ! ! +1w0t_A ! ! +-7 ------------YTVCKGDCKC---------- L -22 ! +2qhb_A ! ! --------------------KG--NA--EC-- L ! +------------------1xpx_A ! ------------RGKGSGSAQAVCRT------ L +----------------------------5gzb_A |
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updated Sat Aug 2 09:14:31 2025