6es3_K : 3D-footprint complex

structure name	STRUCTURE OF CDX2-DNA(TCG) (Homeobox protein CDX-2)
reference	Morgunova et al. Elife 7 ? 2018
source	Homo sapiens
experiment	X-ray (resolution=2.57, R-factor=0.222)
structural superfamily	Homeodomain-like;
sequence family	Homeobox domain;
redundant complexes	5lty_K 6es2_K 7q4n_C
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6es3_K interface=6,7,49,52,53, rtkdkYRvvytdhqrlelekefhysryitirrkaelaatlglserqvkIwfQNrrakerkinkkklqqqqqq
interface signature	YRIQN

Estimated binding specificities ?

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# IC=4.046 IC/col=0.809 n_of_columns=5

specificity:

A |   9   9   0  96   9
C |   9   9   0   0  69
G |   9  11   0   0   9
T |  69  67  96   0   9

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: CDX2
TATAAAA	PubMed	5lty_M(1.09e-02), 6es2_K(1.05e-02)
GTTTAGA	PubMed	5lty_M(1.09e-02), 6es2_K(1.05e-02)
TTTTAGG	PubMed	5lty_M(1.09e-02), 6es2_K(1.05e-02)
GTTTATG	PubMed	5lty_M(1.09e-02), 6es2_K(1.05e-02)

Dendrogram of similar interfaces ?

matrix format

  
  RARA--IAQTNA----   L                               +-5ego_B    
                                      +--------------1 
  --RT--NT--NAIARG   L   +------------2              +-1b72_B    
                         !            ! 
  ----RTNT--NAIARG   L --3            +----------------4cyc_B    
                         ! 
  --RT--VTQTNA--RG   L   +-----------------------------8ejp_B

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updated Sat Jan 10 10:05:01 2026