interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF CDX2-DNA(TCG)
(Homeobox protein CDX-2)
referenceMorgunova et al. Elife 7 ? 2018
sourceHomo sapiens
experimentX-ray (resolution=2.57, R-factor=0.222)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
redundant complexes5lty_K 6es2_K 7q4n_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureYRIQN

Estimated binding specificities ?

readout + contactlogo
# IC=4.007 IC/col=0.801 n_of_columns=5 specificity:   
A |   9   9   0  96   9
C |  11   9   0   0  67
G |   9   9   0   0  11
T |  67  69  96   0   9
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: CDX2
TATAAAAPubMed5lty_M(1.09e-02), 6es2_K(1.05e-02)
GTTTAGAPubMed5lty_M(1.09e-02), 6es2_K(1.05e-02)
TTTTAGGPubMed5lty_M(1.09e-02), 6es2_K(1.05e-02)
GTTTATGPubMed5lty_M(1.09e-02), 6es2_K(1.05e-02)

Dendrogram of similar interfaces ?

matrix format
  
  ----RA------YAQTNAAARG--   L     +-----------------------------6wig_A    
                                   ! 
  KG--RT------IAQCNAYA--RT   L     !                            +1nk2_P    
                                   !   +------------------------3 
  RC--RT------NT--NAITRG--       +-9   !                        +5zjt_B    
                                 ! !   ! 
  ----RT--RT--IAQCNA------   L   ! !   !                         +5jlw_D    
                                 ! !   !                       +-1 
  ----RT------NT--NAIARG--   L   ! +---8                       ! +1b72_B    
                                 !     !         +-------------4 
  ----RT------ITQCNAACRG--   L   !     !         !             ! +6a8r_A    
                                 !     !   +-----6             +-2 
  --RC--RT----NCSTNARG----   L -10     !   !     !               +1mnm_C    
                                 !     !   !     ! 
  ----------RCVACTNAQA----   L   !     +---7     +---------------7xrc_C    
                                 !         ! 
  ----RT----FTYAQTNAATRG--   L   !         !                +----6ryd_F    
                                 !         +----------------5 
  ----------RTVAITNAMCRG--   L   !                          +----1yrn_A    
                                 !  
  --------------KC--YCFAKC       +-----------------------------6p5a_B    
                               

home
updated Fri Sep 13 21:37:05 2024