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structure nameICP4 DNA-BINDING DOMAIN, LACKING INTRINSICALLY DISORDERED REGION, IN COMPLEX WITH 12MER DNA DUPLEX FROM ITS OWN PROMOTER
(Major viral transcription factor ICP4)
referenceLockhart-Cairns et al. 'Nucleic 45 8064 2017
sourceHuman herpesvirus 1 (strain 17) / Human herpesvirus 1 (strain 17)
experimentX-ray (resolution=2.12, R-factor=0.199)
sequence familyHerpesvirus ICP4like protein Ntermina;
multimeric complexes5mhj_AB 5mhk_AB 5mhk_CDJ
redundant complexes5mhk_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSSRR

Estimated binding specificities ?

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# IC=3.101 IC/col=0.775 n_of_columns=4 specificity:   
A |  54   0   0  54
C |  13  96   0  13
G |  13   0  96  13
T |  16   0   0  16
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: ICP4
ATCGTCPubMed5mhj_A(3.59e-04), 5mhj_AB(1.37e-07)
TCGTCPubMed5mhj_A(1.36e-04), 5mhj_AB(1.48e-04)
ATCGTPubMed5mhj_A(1.36e-04), 5mhj_AB(2.95e-08)
ATCGTNNNNNCGGPubMed5mhj_A(8.64e-03), 5mhj_AB(1.92e-05)
ATCGTCNNNNPubMed5mhj_A(4.11e-03), 5mhj_AB(6.56e-06)

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updated Fri Sep 13 20:01:03 2024