structure nameCRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 6'A7' ON THE TARGET STRAND
(TtAgo D546N)
referenceSheng et al. 'Nucleic 45 9149 2017
sourceThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) / Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
experimentX-ray (resolution=2.90, R-factor=0.216)
structural superfamilyRibonuclease H-like;
sequence familyPiwi domain 536;
multimeric complexes3hk2_AB 3hvr_AB
reference complex4n41_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureREVYPRTSMWRINHRNRRDF

Estimated binding specificities ?

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# IC=10.269 IC/col=0.540 n_of_columns=19 specificity:   
A |   0   0  24   0  24  16  24  16   0  72  24  24  24  24  24  24  96   0  96
C |   0   0  24   0  24  16  24  16   0   8  24  24  24  24  24  24   0   0   0
G |   0  96  24  96  24  16  24  56   0   8  24  24  24  24  24  24   0   0   0
T |  96   0  24   0  24  48  24   8  96   8  24  24  24  24  24  24   0  96   0
scan!

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updated Sat Aug 2 09:57:29 2025