5xow_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 6'A7' ON THE TARGET STRAND (TtAgo D546N)
reference	Sheng et al. 'Nucleic 45 9149 2017
source	Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) / Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
experiment	X-ray (resolution=2.90, R-factor=0.216)
structural superfamily	Ribonuclease H-like;
sequence family	Piwi domain 536;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5xow_A interface=38,39,41,42,43,191,265,279,412,414,417,433,435,444,445,448,485,607,608,646, nhlgktevflnrfalrplnpeelrpwrlevvldpppgREeVYPllaqvarraggvtvrmgdglaswsppevlvlegtlarmgqtyayrlypkgrrpldpkdpgersvlsalarrllqerlrrlegvwveglavyrrehargpgwrvlggavldlwvsdsgafllevdpayrilcemsleawlaqghplpkRvrnaydrrtwellrlgeedpkelplpgglslldyhaskgrlqgreggrvawvadpkdprkpiphltgllvpvlTledlheeegslalSlpweerrrrtreiaswigrrlglgtpeavraqayrlsipklmgrravskpadalrvgfyraqetalallrldgaqgwpeflrrallrafgasgaslrlhtlhahpsqglafrealrkakeegvqavlvltppMaWedRnrlkalllreglpsqIlNvplreeerHRweNallgllakaglqvvalsgaypaelavgfdaggresfRfggaacavggdgghllwtlpeaqageripqevvwdlleetlwafrrkagrlpsrvlllrngrvpqdefalalealaregiaydlvsvrksgggrvypvqgrladglyvpledktfllltvhRDfrgtprplklvheagdtplealahqifhltrlypasgFafprlpaplhladrlvkevgrlgirhlkevdreklffv
interface signature	REVYPRTSMWRINHRNRRDF

Estimated binding specificities ?

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# IC=10.627 IC/col=0.559 n_of_columns=19

specificity:

A |   0   0  24   0  24  16  24  16   0  72  24  24  24  24  24  24  96   0  96
C |   0   0  24   0  24  16  24  16   0   8  24  24  24  24  24  24   0   0   0
G |   0  96  24  96  24   8  24  64   0   8  24  24  24  24  24  24   0   0   0
T |  96   0  24   0  24  56  24   0  96   8  24  24  24  24  24  24   0  96   0

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updated Tue Dec 17 02:56:31 2024