interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 9'U10' ON THE TARGET STRAND
(Uncharacterized protein Ago)
referenceSerganov et al. 'Nucleic 45 9149 2017
sourceThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) / Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
experimentX-ray (resolution=2.90, R-factor=0.218)
structural superfamilyRibonuclease H-like;
sequence familyPiwi domain 508;
multimeric complexes3hk2_AB 3hvr_AB
reference complex4n41_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureLSMWRINHRNFF

Estimated binding specificities ?

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# IC=4.131 IC/col=0.516 n_of_columns=8 specificity:   
A |   0   0  24  24  10  24  33   0
C |   0   0  24  24  23  24  21   0
G |   0  96  24  24  42  24  21  96
T |  96   0  24  24  21  24  21   0
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updated Sat Aug 2 09:57:35 2025