5xpg_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 6'U7' ON THE TARGET STRAND (Uncharacterized protein)
reference	Serganov et al. 'Nucleic 45 9149 2017
source	Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) / Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
experiment	X-ray (resolution=2.80, R-factor=0.205)
structural superfamily	Ribonuclease H-like;
sequence family	Piwi domain 536;
multimeric complexes	3hk2_AB 3hvr_AB
reference complex	4n41_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5xpg_A interface=38,41,42,43,191,412,414,417,433,435,444,445,448,485,608,646, nhlgktevflnrfalrplnpeelrpwrlevvldpppgReeVYPllaqvarraggvtvrmgdglaswsppevlvlegtlarmgqtyayrlypkgrrpldpkdpgersvlsalarrllqerlrrlegvwveglavyrrehargpgwrvlggavldlwvsdsgafllevdpayrilcemsleawlaqghplpkRvrnaydrrtwellrlgeedpkelplpgglslldyhaskgrlqgreggrvawvadpkdprkpiphltgllvpvltledlheeegslalslpweerrrrtreiaswigrrlglgtpeavraqayrlsipklmgrravskpadalrvgfyraqetalallrldgaqgwpeflrrallrafgasgaslrlhtlhahpsqglafrealrkakeegvqavlvltppMaWedRnrlkalllreglpsqIlNvplreeerHRweNallgllakaglqvvalsgaypaelavgfdaggresfRfggaacavggdgghllwtlpeaqageripqevvwdlleetlwafrrkagrlpsrvlllrngrvpqdefalalealaregiaydlvsvrksgggrvypvqgrladglyvpledktfllltvhrDfrgtprplklvheagdtplealahqifhltrlypasgFafprlpaplhladrlvkevgrlgirhlkevdreklffv
interface signature	RVYPRMWRINHRNRDF

Estimated binding specificities ?

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# IC=7.165 IC/col=0.377 n_of_columns=19

specificity:

A |   0   0  31  16  24  24  24  21  12  31  24  24  21  24  24  24  96   0  96
C |   0   0  21  16  24  24  24  23  12  21  24  24  23  24  24  24   0   0   0
G |   0  96  21  48  24  24  24  31  12  21  24  24  21  24  24  24   0   0   0
T |  96   0  23  16  24  24  24  21  60  23  24  24  31  24  24  24   0  96   0

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updated Sat Aug 2 09:57:48 2025