6crm_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF RECQ CATALYTIC CORE FROM C. SAKAZAKII BOUND TO AN UNFOLDED G-QUADRUPLEX (RECQ)
reference	Voter et al. 'Nat 9 4201 2018
source	CRONOBACTER SAKAZAKII (STRAIN ATCC BAA-894) / CRONOBACTER SAKAZAKII (STRAIN ATCC BAA-894)
experiment	X-ray (resolution=2.19, R-factor=0.207)
structural superfamily	P-loop containing nucleoside triphosphate hydrolases;
sequence family	RQC domain; DEAD/DEAH box helicase; Helicase conserved Cterminal domain;
redundant complexes	4tmu_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6crm_A interface=97,100,120,149,150,154,155,216,239,240,241,244,308,311,340,343,347,350,351, evysqetlakqvlqetfgyqqfrpgqatiidavlegrdclvvmptgggkslcyqipalvktgltivvsplislmkdqvdqllangvaaaclnstqsReeQqavlagcrtgqvrllyiapErlmmdnfidtlgywdlamvavdeahcisQWghdFRpeyaalgqlrarfpavpfmaltataddttrrdivrllglddplieissfdrpnirymlmeKfkpldqlmryvqeqrgksgiiyCNSraKvedtaarlqsrgisaaayhaglehevrasvqekfqrddlqivvatvafgmginkpnvrfvvhfDipRniesyyqetgragrdglpaeamlfydpaDmaWlrrCleEKapgplqdierhklnamgafaeaqtcrrlvllnyfgegrqapcgncdicldpprrydglvdaqkalsaiarveqrfgmgyvvevlrgannqrirelghdklkvygigrdqsqehwvsvirqlihlgvvtqniaqhsalqlteaarpflrgeaplmlavprva
interface signature	RQEQWFRKCNSKDRDWCEK

Estimated binding specificities ?

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# IC=8.690 IC/col=0.790 n_of_columns=11

specificity:

A |   0  24   0   0   0   0   0   7  24  24  16
C |   0  24  96   0   0   0   0  74  24  24  16
G |  96  24   0  96  96   0  96   7  24  24  19
T |   0  24   0   0   0  96   0   8  24  24  45

scan!

Dendrogram of similar interfaces ?

matrix format

  
  --SC------------   L     +-----------------------------6kw4_Y    
                         +-2 
  WTLT------------   L   ! +-----------------------------5vhe_A    
                       --3 
  ----NGSARGHGSC--   L   !                 +-----------6el8_A    
                         +-----------------1 
  ------RC--YG--KT                         +-----------2acj_B

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updated Mon Jun 29 22:29:47 2026