structure nameHUMAN HOLO-PIC IN THE CLOSED STATE
sourceHOMO SAPIENS
experimentNMR
structural superfamilyCyclin-like;Zinc beta-ribbon;Transcription factor IIA TFIIA, beta-barrel domain;Transcription factor IIA TFIIA, alpha-helical domain;TATA-box binding protein-like;Rap30/74 interaction domains;"Winged helix" DNA-binding domain;P-loop containing nucleoside triphosphate hydrolases;
reference complex5iy6_M 5iy6_N 5iy6_P 5iy6_T 5iy6_V
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKE/GK/AVTR//NFLTNVFLFVT/KH

Estimated binding specificities ?

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# IC=13.774 IC/col=0.299 n_of_columns=46 specificity:   
A |   0  24  24  10  96   5  96  96  24   0  24  24  24  24  24  24  24   0   0  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  80  96  12  24  24   5
C |   0  24  24  10   0   6   0   0  24   0  24  24  24  24  24  24  24   0  96  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   5   0  69  24  24  80
G |  96  24  24  10   0   5   0   0  24  96  24  24  24  24  24  24  24  96   0  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   5   0   5  24  24   5
T |   0  24  24  66   0  80   0   0  24   0  24  24  24  24  24  24  24   0   0  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   6   0  10  24  24   6
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updated Tue Jan 6 09:22:28 2026