structure nameHUMAN HOLO-PIC IN THE CLOSED STATE
sourceHOMO SAPIENS
experimentNMR
structural superfamilyCyclin-like;Zinc beta-ribbon;Transcription factor IIA TFIIA, beta-barrel domain;Transcription factor IIA TFIIA, alpha-helical domain;TATA-box binding protein-like;Rap30/74 interaction domains;"Winged helix" DNA-binding domain;P-loop containing nucleoside triphosphate hydrolases;
reference complex5iy6_M 5iy6_N 5iy6_P 5iy6_T 5iy6_V
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKE/GK/AVTR//NFLTNVFLFVT/KH

Estimated binding specificities ?

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# IC=13.295 IC/col=0.289 n_of_columns=46 specificity:   
A |   9  24  24   9   0  11  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   0   0  24  24  24  24  24  24  24   0  24   0   0  96   0  24  24  24   0
C |   9  24  24   9   0   9  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   0  96  24  24  24  24  24  24  24  96  24   0   0   0   0  24  24  24  96
G |  67  24  24  67   0   9  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  96   0  24  24  24  24  24  24  24   0  24   0   0   0   0  24  24  24   0
T |  11  24  24  11  96  67  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   0   0  24  24  24  24  24  24  24   0  24  96  96   0  96  24  24  24   0
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updated Wed Jul 30 22:34:34 2025