structure nameHUMAN HOLO-PIC IN THE CLOSED STATE
sourceHOMO SAPIENS
experimentNMR
structural superfamilyCyclin-like;Zinc beta-ribbon;Transcription factor IIA TFIIA, beta-barrel domain;Transcription factor IIA TFIIA, alpha-helical domain;TATA-box binding protein-like;Rap30/74 interaction domains;"Winged helix" DNA-binding domain;P-loop containing nucleoside triphosphate hydrolases;
reference complex5iy6_M 5iy6_N 5iy6_P 5iy6_T 5iy6_V
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKE/GK/AVTR//NFLTNVFLFVT/KH

Estimated binding specificities ?

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# IC=13.773 IC/col=0.299 n_of_columns=46 specificity:   
A |   0  24  24  11  96   7  96  96  24   0  24  24  24  24  24  24  24   0   0  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  79  96  11  24  24   0
C |   0  24  24  12   0   5   0   0  24   0  24  24  24  24  24  24  24   0  96  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   5   0  67  24  24  84
G |  96  24  24  11   0   5   0   0  24  96  24  24  24  24  24  24  24  96   0  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   5   0   5  24  24   5
T |   0  24  24  62   0  79   0   0  24   0  24  24  24  24  24  24  24   0   0  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   7   0  13  24  24   7
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updated Thu Jun 25 20:12:14 2026