6vgd_AD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN (DBD) OF HUMAN FLI1 AND THE COMPLEX OF THE DBD OF HUMAN RUNX2 WITH CORE BINDING FACTOR BETA (CBFB), IN COMPLEX WITH 16MER DNA CAGAGGATGTGGCTTC
reference	Tsodikov et al. Structure 29 404 2021
source	HOMO SAPIENS
experiment	X-ray (resolution=4.20, R-factor=?)
structural superfamily	"Winged helix" DNA-binding domain;p53-like transcription factors;
reference complex	4iri_A 6vgd_D
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6vgd_A interface=63,66,67, mpgsgqiqlwqfllellsdsanascitwegtngefkmtdpdevarrwgerkskpnmnydklsRalRYyydknimtkvhgkryaykfdfhgiaqalqph > 6vgd_D interface=21,83,111,112,115, aelvrtdspnflcsvlpshwRcnktlpvafkvvalgevpdgtvvtvmagndenysaelrnasavmknqvarfndlrfvgrsgRgksftltitvftnppqvatyhraikvtVDgpRep
interface signature	RRY/RRVDR

Estimated binding specificities ?

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# IC=11.515 IC/col=1.047 n_of_columns=11

specificity:

A |  96   0   0   0   0   0   0   0  24  20   0
C |   0   0   0   0   0   0   0   0  24  19   1
G |   0  96  96   0  96   0  96  96  24  19  19
T |   0   0   0  96   0  96   0   0  24  38  76

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updated Tue Sep 10 22:05:54 2024