6vgd_D : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN (DBD) OF HUMAN FLI1 AND THE COMPLEX OF THE DBD OF HUMAN RUNX2 WITH CORE BINDING FACTOR BETA (CBFB), IN COMPLEX WITH 16MER DNA CAGAGGATGTGGCTTC (RUNT-RELATED TRANSCRIPTION FACTOR 2)
reference	Tsodikov et al. Structure 29 404 2021
source	HOMO SAPIENS
experiment	X-ray (resolution=4.20, R-factor=0.295)
structural superfamily	p53-like transcription factors;
sequence family	Runt domain;
multimeric complexes	6vgd_AD 6vge_AD 6vgg_AD
redundant complexes	6vge_D 6vgg
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6vgd_D interface=21,83,111,112,115, aelvrtdspnflcsvlpshwRcnktlpvafkvvalgevpdgtvvtvmagndenysaelrnasavmknqvarfndlrfvgrsgRgksftltitvftnppqvatyhraikvtVDgpRep
interface signature	RRVDR

Estimated binding specificities ?

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# IC=3.947 IC/col=0.789 n_of_columns=5

specificity:

A |   9   0   0  19   9
C |  19   0   0   9  11
G |   9  96   0  67  67
T |  59   0  96   1   9

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Dendrogram of similar interfaces ?

matrix format

  
  RG--RAVCDC----RT   L                             +6vgd_D    
                                +------------------1 
  RG--RTVCDC----RG   L          !                  +3wu1_A    
                         +------3 
  ------STNT----QT       !      !                  +1bg1_A    
                       --4      +------------------2 
  KC----STNTVGSTQT   L   !                         +1bf5_A    
                         ! 
  --RG--TTAT------       +--------------------------4a04_B

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updated Sat Sep 14 00:06:55 2024