6vge_AD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE DNA BINDING DOMAINS OF HUMAN TRANSCRIPTION FACTOR ERG, HUMAN RUNX2 BOUND TO CORE BINDING FACTOR BETA (CBFB), IN COMPLEX WITH 16MER DNA CAGAGGATGTGGCTTC
reference	Tsodikov et al. Structure 29 404 2021
source	HOMO SAPIENS
experiment	X-ray (resolution=4.25, R-factor=?)
structural superfamily	"Winged helix" DNA-binding domain;p53-like transcription factors;
reference complex	4iri_A 6vgd_D
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6vge_A interface=60,63,66,67, mpgsgqiqlwqfllellsdssnsscitwegtngefkmtdpdevarrwgerkskpnmnydKlsRalRYyydknimtkvhgkryaykfdfhgiaqalqph > 6vge_D interface=21,83,111,112,115, aelvrtdspnflcsvlpshwRcnktlpvafkvvalgevpdgtvvtvmagndenysaelrnasavmknqvarfndlrfvgrsgRgksftltitvftnppqvatyhraikvtVDgpRep
interface signature	KRRY/RRVDR

Estimated binding specificities ?

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# IC=10.773 IC/col=0.898 n_of_columns=12

specificity:

A |  15  64  24   0   5  96   0  77   0  13   0   4
C |   9  18  24  96  73   0  96   9   0  83  96   0
G |   4  10  24   0   9   0   0   6   0   0   0   4
T |  68   4  24   0   9   0   0   4  96   0   0  88

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updated Tue Jan 6 14:55:57 2026