4iri_A : 3D-footprint complex

structure name	AUTO-INHIBITED ERG ETS DOMAIN-DNA COMPLEX (Transcriptional regulator ERG)
reference	Bushweller et al. Proc.Natl.Acad.Sci.USA 110 13374 2013
source	Homo sapiens
experiment	X-ray (resolution=2.77, R-factor=0.191)
structural superfamily	"Winged helix" DNA-binding domain;
sequence family	Etsdomain;
multimeric complexes	6vge_AD 6vgg_AD
redundant complexes	6vgg_A 6vge
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4iri_A interface=56,59,60,62,63, gqiqlwqfllellsdssnsscitwegtngefkmtdpdevarrwgerkskpnmnydKlsRAlRYyydknimtkvhgkryaykfdfhgiaqalqph
interface signature	KRARY

Estimated binding specificities ?

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# IC=5.582 IC/col=0.930 n_of_columns=6

specificity:

A |  12  12   0   0   0   0
C |  60  12   0  96  96   0
G |  12  12  12   0   0  96
T |  12  60  84   0   0   0

scan!

Dendrogram of similar interfaces ?

matrix format

  
  DCKT--RG----RGYA----KA   L                                  +5jvt_A    
                                         +--------------------1 
  DCKT--RGST--RGYA------   L     +-------2                    +4bnc_A    
                                 !       ! 
  ------NT--RGSTAT--RA--   L   +-3       +---------------------2o6g_G    
                               ! ! 
  QCKT--RGAT--RGNT------   L --4 +-----------------------------8smh_F    
                               ! 
  ----NAST--RGHT--STFT--   L   +-----------------------------1vtn_C

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updated Sat Jan 10 07:10:25 2026