interface graph thumbnail
legend  pdf

structure nameAUTO-INHIBITED ERG ETS DOMAIN-DNA COMPLEX
(Transcriptional regulator ERG)
referenceBushweller et al. Proc.Natl.Acad.Sci.USA 110 13374 2013
sourceHomo sapiens
experimentX-ray (resolution=2.77, R-factor=0.191)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
multimeric complexes5jvt_AD 6vg8_AD 6vgd_AD 6vge_AD 6vgg_AD
redundant complexes5e8i_A 5jvt_G 6vg2_D 6vgg_A 6vg8 6vgd 6vge
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKRARY

Estimated binding specificities ?

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# IC=5.807 IC/col=0.968 n_of_columns=6 specificity:   
A |   0   0   0  96  54  13
C |  96   0   0   0  16  13
G |   0  96  96   0  13  57
T |   0   0   0   0  13  13
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --ECKTRGATRGHTRA   L                              +---4mhg_A    
                                                  +-1 
  ----KTRG--RGYT--   L   +------------------------2 +---4bqa_A    
                         !                        ! 
  ----KTRG--RGYA--   L --3                        +----4l18_B    
                         ! 
  ST--TCQG----RG--       +-----------------------------7b24_C    
                       

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updated Fri Sep 13 18:24:19 2024