4iri_A : 3D-footprint complex

structure name	AUTO-INHIBITED ERG ETS DOMAIN-DNA COMPLEX (Transcriptional regulator ERG)
reference	Bushweller et al. Proc.Natl.Acad.Sci.USA 110 13374 2013
source	Homo sapiens
experiment	X-ray (resolution=2.77, R-factor=0.191)
structural superfamily	"Winged helix" DNA-binding domain;
sequence family	Etsdomain;
multimeric complexes	5jvt_AD 6vg8_AD 6vgd_AD 6vge_AD 6vgg_AD
redundant complexes	5e8i_A 5jvt_G 6vg2_D 6vgg_A 6vg8 6vgd 6vge
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4iri_A interface=56,59,60,62,63, gqiqlwqfllellsdssnsscitwegtngefkmtdpdevarrwgerkskpnmnydKlsRAlRYyydknimtkvhgkryaykfdfhgiaqalqph
interface signature	KRARY

Estimated binding specificities ?

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# IC=5.582 IC/col=0.930 n_of_columns=6

specificity:

A |  12  12   0   0   0   0
C |  60  12   0  96  96   0
G |  12  12  12   0   0  96
T |  12  60  84   0   0   0

scan!

Dendrogram of similar interfaces ?

matrix format

  
  --ECKTRGATRGHTRA   L                              +---4mhg_A    
                                                  +-1 
  ----KTRG--RGYT--   L   +------------------------2 +---4bqa_A    
                         !                        ! 
  ----KTRG--RGYA--   L --3                        +----4l18_B    
                         ! 
  ST--TCQG----RG--       +-----------------------------7b24_C

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updated Sun Aug 3 08:10:05 2025