6vgg_AD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE DNA BINDING DOMAINS OF HUMAN TRANSCRIPTION FACTOR ERG, HUMAN RUNX2 BOUND TO CORE BINDING FACTOR BETA (CBFB), AND MITHRAMYCIN, IN COMPLEX WITH 16MER DNA CAGAGGATGTGGCTTC
reference	Tsodikov et al. Structure 29 404 2021
source	HOMO SAPIENS
experiment	X-ray (resolution=4.31, R-factor=?)
structural superfamily	"Winged helix" DNA-binding domain;p53-like transcription factors;
reference complex	4iri_A 6vgd_D
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6vgg_A interface=60,63,66,67, mpgsgqiqlwqfllellsdssnsscitwegtngefkmtdpdevarrwgerkskpnmnydKlsRalRYyydknimtkvhgkryaykfdfhgiaqalqph > 6vgg_D interface=21,83,111,112,115, aelvrtdspnflcsvlpshwRcnktlpvafkvvalgevpdgtvvtvmagndenysaelrnasavmknqvarfndlrfvgrsgRgksftltitvftnppqvatyhraikvtVDgpRep
interface signature	KRRY/RRVDR

Estimated binding specificities ?

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# IC=13.803 IC/col=1.062 n_of_columns=13

specificity:

A |  13  96   0   0  96   0   0   0   0   0  24  13   0
C |  13   0   0   0   0   0   0   0   0   0  24  13   0
G |  54   0  96  96   0   0  96   0  96  96  24  13   0
T |  16   0   0   0   0  96   0  96   0   0  24  57  96

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updated Tue Sep 10 22:06:10 2024