interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE SMAD3-SMAD5 MH1 DOMAIN CHIMERA BOUND TO THE GGCGC SITE
(Mothers against decapentaplegic homolog 3)
referenceMacias et al. 'Comput 19 632 2021
sourceHomo sapiens
experimentX-ray (resolution=2.33, R-factor=0.212)
structural superfamilySMAD MH1 domain;
sequence familyMH1 domain;
multimeric complexes1mhd_AB 1ozj_AB
reference complex5od6_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureDRQK

Estimated binding specificities ?

readout + contactlogo
# IC=2.714 IC/col=0.678 n_of_columns=4 specificity:   
A |   9   9   9   0
C |  67   9  69  96
G |  11  69   9   0
T |   9   9   9   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --RGQAHTKG   L     +-----------------------------5x6g_A    
                   +-2 
  --RGQA--KG   L   ! +-----------------------------3kmp_A    
                 --3 
  DCRGQC--KG   L   !                             +6zmn_B    
                   +-----------------------------1 
  DCRGQC--KG   L                                 +6fzt_A

home
updated Sat Aug 2 15:43:22 2025