7nvr_7AEMORU : 3D-footprint complex

structure name	HUMAN MEDIATOR WITH RNA POLYMERASE II PRE-INITIATION COMPLEX
source	HOMO SAPIENS / SUS SCROFA
experiment	NMR
structural superfamily	Cyclin-like;Zinc beta-ribbon;Transcription factor IIA TFIIA, beta-barrel domain;Transcription factor IIA TFIIA, alpha-helical domain;TATA-box binding protein-like;Rap30/74 interaction domains;"Winged helix" DNA-binding domain;Eukaryotic RPB5 N-terminal domain;RPB5-like RNA polymerase subunit;
reference complex	5iy6_M 5iy6_N 5iy6_P 5iy6_T 7nvy_E
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7nvr_7 interface=494,514, tkvdeygakdyrlqmplkddhtsrplwvapdghifleafspvykyaqdflvaiaepvcrpthvheykltayslyaavsvglqtsditeylrklsktgvpdgimqfiklctvsygkvklvlkhnryfveschpdviqhllqdpvirecrlrqtvsfevkqemieelqkrcihleypllaeydfrndsvnpdinidlkptavlrpyqekslrkmfgngrarsgvivlpcgagkslvgvtaactvrkrclvlgnsavsveqwkaqfkmwstiddsqicrftsdakdkpigcsvaistysmlghttkrsweaervmewlktqewglmildevhtipakmfrrvltivqahcklgltatlvreddkivdlnfligpklyeanwmelqnngyiakvqcaevwcpmspefyreyvaiktkkrillytmnpnkfracqflikfherrndkiivfadnvfalkeyairlnkpyiygptsqgermqilqnfkhnpkintifisKvgdtsfdlpeanvliqissHggsrrqeaqrlgrvlrakkgmvaeeynaffyslvsqdtqemaystkrqrflvdqgysfkvitklagmeeedlafstkeeqqqllqkvlaat > 7nvr_A interface= sacplrtikrvqfgvlspdelkrmsvteggikypetteggrpklgglmdprqgviertgrcqtcagnmtecpghfghielakpvfhvgflvktmkvlrcvcffcskllvdsnnpkikdilakskgqpkkrlthvydlckgkniceggcgryqprirrsglelyaewkkillspervheifkrisdeecfvlgmepryarpewmivtvlpvpplsvrpavvmqgsarnqddlthkladivkinnqlrrneqngaaahviaedvkllqfhvatmvdnelpglpramqksgrplkslkqrlkgkegrvrgnlmgkrvdfsartvitpdpnlsidqvgvprsiaanmtfaeivtpfnidrlqelvrrgnsqypgakyiirdngdridlrfhpkpsdlhlqtgykverhmcdgdivifnrqptlhkmsmmghrvrilpwstfrlnlsvttpynadfdgdemnlhlpqsletraeiqelamvprmivtpqsnrpvmgivQdtltavrkftkrdvflergEvmnllmflstwdgkvpqpailkprplwtgkqifsliipghincirthsthpddedsgpykhispgdtkvvvengelimgilckkslgtsagslvhisylemghditrlfysniqtvinnwllieghtigigdsiadsktyqdiqntikkakqdvieviekahnneleptpgntlrqtfenqvnrilndardktgssaqkslseynnfksmvvsgakgskinisqviavvgqqnvegkripfgfkhrtlphfikddygpesrgfvensylagltptefffhamggreglidtavktaetgyiqrrliksmesvmvkydatvrnsinqvvqlrygedglagesvefqnlatlkpsnkafekkfrfdytneralrrtlqedlvkdvlsnahiqnelerefermredrevlrvifptgdskvvlpcnllrmiwnaqkifhinprlpsdlhpikvvegvkelskklvivngddplsrqaqenatllfnihlrstlcsrrmaeefrlsgeafdwllgeieskfnqaiahpgemvgalaaqslgepatqmtlnknvtlgvprlkeliniskkpktpsltvfllgqsardaerakdilcrlehttlrkvtantaiyydpnpqstvvaedqewvnvyyempdfdvarispwllrveldrkhmtdrkltmeqiaekinagfgddlncifnddnaeklvlririmnsdenkmdddvflrciesnmltdmtlqgieqiskvymhlpqtdnkkkiiitedgefkalqewiletdgvslmrvlsekdvdpvrttsndiveiftvlgieavrkalerelyhvisfdgsyvnyrhlallcdtmtcrghlmaitrhgvnrqdtgplmkcsfeetvdvlmeaaahgesdpmkgvsenimlgqlapagtgcfdllldaekckygmeip > 7nvr_E interface= ddeeetyrlwkirktimqlchdrgylvtqdeldqtleefkaqfgdkpsegrprrtdltvlvahnddptdqmfvffpeepkvgiktikvycqrmqeenitralivvqqgmtpsakqslvdmapkyileqflqqellinitehelvpehvvmtkeevtellaryklrenqlpriqagdpvaryfgikrgqvvkiirpsetagryityrlvq > 7nvr_M interface= tcpnhpdailvedyragdmicpecglvvgdrvidvgsewrttmsssdrammnafkeittmadrinlprnivdrtnnlfkqvyeqkslkgrandaiasaclyiacrqegvprtfkeicavsriskkeigrcfklilkaletsvdlittgdfmsrfcsnlclpkqvqmaathiarkaveldlvpgrspisvaaaaiymasqasaekrtqkeigdiagvadvtirqsyrliyprapdlfptdfkfdtpvdklpql > 7nvr_O interface=9,11,39,54,56,62,64,99,101,130,131,145,147,153,155, sgivpqlqNiVstvnlgckldlktialrarnaeynpkrFaavimrireprttaLiFssgkmVcTgakseeqsrlaarkyarvvqklgfpakfldfkiqNmVgscdvkfpirleglvlthqqfssyepelFPgliyrmikprivlLiFvsgkvVlTgakvraeiyeafeniypilkgfrk > 7nvr_R interface=158, aergeldltgakqntgvwlvkvpkylsqqwakasgrgevgklriaktqgrtevsftlnedlanehpfvlqsvggqtltvftesssdklslegivvqraecrpaasenymrlkrlqieesskpvrlsqqldkvvttnykpvanhqynieyerkkkedgKraradkqhvldmlfsafekhqyynlkdlvditkqpvvylkeilkeigvqnvkgihkntwelkpe > 7nvr_U interface= tvpklyrsviedvindvrdiflddgvdeqvlmelktlwenklmgqveeeplnseddvsdeegqelfdtenvvvcqydkihrsknkwkfhlkdgimnlngrdyifskaigdaew
interface signature	KH/QE///NVFLFVTNVFPLFVT/K/

Estimated binding specificities ?

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# IC=12.429 IC/col=0.264 n_of_columns=47

specificity:

A |   0  96   0  96  96  96  96   0  16  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  13   0
C |   0   0   0   0   0   0   0   0  13  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  54   0
G |   0   0   0   0   0   0   0  96  54  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  16  96
T |  96   0  96   0   0   0   0   0  13  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  13   0

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updated Fri Jun 26 14:55:04 2026