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3D-footprint cannot reliably estimate the specificity of 'Nucleic acid-binding proteins', as they bind to single-stranded DNA and thus accumulate more base contacts.


Dendrogram of similar interfaces ?

matrix format
structure nameCRYO-EM STRUCTURE OF HUMAN TELOMERASE-DNA-TPP1-POT1 COMPLEX (WITH POT1 SIDE CHAINS)
(PROTECTION OF TELOMERES PROTEIN 1)
referencevan Roon et al. Science 375 1173 2022
sourceHOMO SAPIENS
experimentX-ray (resolution=3.91, R-factor=0.323)
structural superfamilyNucleic acid-binding proteins;
sequence familyTelomerebinding protein alpha subunit, cen;
multimeric complexes7qxb_AP 7qxs_AP
redundant complexes7qxb
reference complex7qxb_P
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
  
  ----KGFGST--TTDT----TG--------TGLA--FT----QGYG--QGIA------------YT----------------------------YGDG----ST--HT--HGYTRT   L                                  +7qxs_P    
                                                                                                                                       +--------------------1 
  ----KGFGST--TTDT----TG--------TGLA--FA----QGYG--QGIA------------YT----------------------------YGDG------HT----HTYTRT   L         +---3                    +3kjp_A    
                                                                                                                                   !   ! 
  --------------------------------------------------------------TGYGSGDGKGATFTSGVG--NGYTLG--KG----------------------RT   L       +-4   +---------------------1s40_A    
                                                                                                                                 ! ! 
  ----------------YTFT----------NT--SG--WG--KGFG--EGKG--KG--EGTG------------------------------------------------------           ! !    +--------------------3u58_C    
                                                                                                                               +-5 +----2 
  --RTTTKT------------TTATNTTTATFTNT----------------------------------------------------------------------------------   L     ! !      +--------------------6bhx_B    
                                                                                                                             +-6 ! 
  NG------STTT--DT--------------QCHC--FA--TGRGYCRCQCLGSGKGDG----------------------------------------------------------       ! ! +--------------------------6bwy_A    
                                                                                                                           --7 ! 
  ----------------------------------------------------------------------------------------------------------RT--------       ! +----------------------------4l5r_C    
                                                                                                                             ! 
  ----------------------------------------------------------------YT--------------NTYT----ETHALTYT--NTRT------KT----LT   L   +----------------------------6lbr_A    
                                                                                                                           

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updated Fri Sep 13 07:25:18 2024