7qxs_P : 3D-footprint complex

3D-footprint cannot reliably estimate the specificity of 'Nucleic acid-binding proteins', as they bind to single-stranded DNA and thus accumulate more base contacts.

Dendrogram of similar interfaces ?

matrix format

structure name	CRYO-EM STRUCTURE OF HUMAN TELOMERASE-DNA-TPP1-POT1 COMPLEX (WITH POT1 SIDE CHAINS) (PROTECTION OF TELOMERES PROTEIN 1)
reference	van Roon et al. Science 375 1173 2022
source	HOMO SAPIENS
experiment	X-ray (resolution=3.91, R-factor=0.323)
structural superfamily	Nucleic acid-binding proteins;
sequence family	Telomerebinding protein alpha subunit, cen;
multimeric complexes	7qxb_AP 7qxs_AP
redundant complexes	7qxb
reference complex	7qxb_P
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7qxs_P interface=25,26,33,36,37,43,53,55,57,82,84,89,91,123,185,186,205,207,218,223,225, atnyiytplnqlkggtivnvygvvKFfkppylSkgTDycsvvTivdqtnvklTcLlFsgnyealpiiykngdivrfhrlkiQvYkketQgItssgfasltfiprtsskyfnflklcdvqpmqYfdltcqllgkaevdgasfllkvwdgtrtpfpswrvliqdlvlegdlshihrlqnltidilvYDnhvhvarslkvgsflriySlHtkllslefhlHggtsYgRgirvlpesnsdvdqlkkdlesanlta

  
  ----KGFGST--TTDT----TG--------TGLA--FT----QGYG--QGIA------------YT----------------------------YGDG----ST--HT--HGYTRT   L                                  +7qxs_P    
                                                                                                                                       +--------------------1 
  ----KGFGST--TTDT----TG--------TGLA--FA----QGYG--QGIA------------YT----------------------------YGDG------HT----HTYTRT   L         +---3                    +3kjp_A    
                                                                                                                                   !   ! 
  --------------------------------------------------------------TGYGSGDGKGATFTSGVG--NGYTLG--KG----------------------RT   L       +-4   +---------------------1s40_A    
                                                                                                                                 ! ! 
  ----------------YTFT----------NT--SG--WG--KGFG--EGKG--KG--EGTG------------------------------------------------------           ! !    +--------------------3u58_C    
                                                                                                                               +-5 +----2 
  --RTTTKT------------TTATNTTTATFTNT----------------------------------------------------------------------------------   L     ! !      +--------------------6bhx_B    
                                                                                                                             +-6 ! 
  NG------STTT--DT--------------QCHC--FA--TGRGYCRCQCLGSGKGDG----------------------------------------------------------       ! ! +--------------------------6bwy_A    
                                                                                                                           --7 ! 
  ----------------------------------------------------------------------------------------------------------RT--------       ! +----------------------------4l5r_C    
                                                                                                                             ! 
  ----------------------------------------------------------------YT--------------NTYT----ETHALTYT--NTRT------KT----LT   L   +----------------------------6lbr_A

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updated Tue Dec 17 12:53:07 2024