interface graph thumbnail
legend  pdf

structure nameHUMAN PU.1 ETS-DOMAIN (165-270) Q226E MUTANT BOUND TO D(AATAAAAGGAAGTGGG)
(Transcription factor PU.1)
referenceTerrell et al. 'Cell 42 112671 2023
sourceHomo sapiens
experimentX-ray (resolution=1.45, R-factor=0.138)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
multimeric complexes8ek8_EF
reference complex8ee9_F
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureEKRARN

Estimated binding specificities ?

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# IC=3.370 IC/col=0.842 n_of_columns=4 specificity:   
A |  74   0   4  78
C |   7   0   4   6
G |   7  96  81   6
T |   8   0   7   6
scan!

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updated Fri Sep 13 10:44:47 2024