interface graph thumbnail
legend  pdf

structure nameHUMAN PU.1 ETS-DOMAIN (165-270) BOUND TO D(AATAAGGAGAAGTAGG)
(Transcription factor PU.1)
referenceTerrell et al. 'Cell 42 112671 2023
sourceHomo sapiens
experimentX-ray (resolution=1.42, R-factor=0.154)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
multimeric complexes8ek8_EF
reference complex8ee9_F
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKRARN

Estimated binding specificities ?

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# IC=3.820 IC/col=0.764 n_of_columns=5 specificity:   
A |   8   8   0   0   8
C |   8  17  96  17  80
G |  11   8   0   1   0
T |  69  63   0  78   8
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updated Fri Jan 9 21:56:10 2026