interface graph thumbnail
legend  pdf

structure nameHUMAN PU.1 ETS-DOMAIN (165-270) Q226E MUTANT BOUND TO D(AATAACCGGAAGTGGG)
(Transcription factor PU.1)
referenceTerrell et al. 'Cell 42 112671 2023
sourceHomo sapiens
experimentX-ray (resolution=1.52, R-factor=0.161)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
multimeric complexes8ek8_EF
reference complex8ee9_F
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureEKRARN

Estimated binding specificities ?

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# IC=5.807 IC/col=0.968 n_of_columns=6 specificity:   
A |  13  13   0   0   0   0
C |  16  13  96  96   0   0
G |  13  13   0   0  96  96
T |  54  57   0   0   0   0
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updated Sun Aug 3 00:00:01 2025