interface graph thumbnail
legend  pdf

structure nameHUMAN PU.1 ETS-DOMAIN (165-270) Q226E MUTANT BOUND TO D(AATAACCGGAAGTGGG)
(Transcription factor PU.1)
referenceTerrell et al. 'Cell 42 112671 2023
sourceHomo sapiens
experimentX-ray (resolution=1.52, R-factor=0.161)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
multimeric complexes8ek8_EF
reference complex8ee9_F
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureEKRARN

Estimated binding specificities ?

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# IC=3.626 IC/col=0.725 n_of_columns=5 specificity:   
A |  13   6   0   6  78
C |  56  78   0   6   6
G |  13   6  96  78   6
T |  14   6   0   6   6
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updated Fri Jan 9 21:58:48 2026