8sst_A : 3D-footprint complex

structure name	ZNFS 1-7 OF CCCTC-BINDING FACTOR (CTCF) K365T MUTANT COMPLEXED WITH 23MER (Transcriptional repressor CTCF)
reference	Horton et al. 'Nucleic 51 8447 2023
source	Homo sapiens
experiment	X-ray (resolution=2.19, R-factor=0.221)
structural superfamily	beta-beta-alpha zinc fingers;
sequence family	Zinc finger, C2H2 type;
redundant complexes	5yef_J 8sss_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8sst_A interface=13,15,16,19,44,69,72,75,79,98,104,128,129,132,154,157,184,186,187,190, tfqcelcsytcpRrSNldRhmkshtderphkchlcgrafrtvtLlrnhlnthtgtrphkcpdcdmafvTsgElvRhrrYkhthekpfkcsmcdyasvEvstlkRhirshtgerpfqcslcsyasrdtYKlkRhmrthsgekpyecyicharftQsgTmkmhilqkhtenvakfhcphcdtviaRkSDlgVhlrkqhs
interface signature	RSNRLTERYERYKRQTRSDV

Estimated binding specificities ?

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# IC=22.280 IC/col=1.061 n_of_columns=21

specificity:

A |   6   0  64   0   0  96   0   0   0   0   6   0   0   0   0  24  24   0   0  96   0
C |  76  96  12   0  96   0   0   0   0   0   6  96   0  96  14  24  24   0   0   0   0
G |   8   0  12  96   0   0  96  96  96  96  78   0  96   0  12  24  24   0  96   0  96
T |   6   0   8   0   0   0   0   0   0   0   6   0   0   0  70  24  24  96   0   0   0

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updated Sun Jan 11 01:21:05 2026