1bf5_A : 3D-footprint complex

structure name	TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX (SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-...)
reference	Darnell Jr. et al. 'Cell(Cambridge,Mass.)' 93 827 1998
source	HOMO SAPIENS
experiment	X-ray (resolution=2.90, R-factor=0.227)
structural superfamily	p53-like transcription factors;SH2 domain;STAT;
sequence family	STAT protein, DNA binding domain; STAT protein, allalpha domain; SH2 domain;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1bf5_A interface=187,272,310,311,312,313,314, ldkqkeldskvrnvkdkvmcieheiksledlqdeydfkcktlqnrehlllkkmylmldnkrkevvhkiiellnvteltqnalindelvewkrrqqsaciggppnacldqlqnwftivaeslqqvrqqlkkleeleqkytyehdpitknkqvlwdrtfslfqqliqssfvverqpcmpthpqrplvlKtgvqftvklrllvklqelnynlkvkvlfdkdvnerntvkgfrkfnilgthtkvmnmeestngslaaefrhlqlkeqknagtrtnEgplivteelhslsfetqlcqpglvidlettslpvvviSNVSQlpsgwasilwynmlvaeprnlsffltppcarwaqlsevlswqfssvtkrglnvdqlnmlgekllgpnaspdglipwtrfckenindknfpfwlwiesilelikkhllplwndgcimgfiskererallkdqqpgtfllrfsessregaitftwversqnggepdfhavepytkkelsavtfpdiirnykvmaaenipenplkylypnidkdhafgkyysrgiktelisvs
interface signature	KESNVSQ

Estimated binding specificities ?

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# IC=5.766 IC/col=0.721 n_of_columns=8

specificity:

A |   0   0  96  54  24  24  13   0
C |   0   0   0  13  24  24  13  96
G |  96   0   0  16  24  24  54   0
T |   0  96   0  13  24  24  16   0

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Dendrogram of similar interfaces ?

matrix format

  
  --------KCEC------STNTVGSTQT   L                               +1bf5_A    
                                                        +--------2 
  ------------------STNT----QT          +---------------3        +1bg1_A    
                                        !               ! 
  ------------KA----VTHG--NTQT   L   +--4               +---------4y5w_B    
                                     !  ! 
  --------RG----RT--VCDC----RG   L   !  !                         +3wu1_A    
                                   --5  +-------------------------1 
  --------RG------RTVCDC----RG   L   !                            +4l0y_A    
                                     ! 
  NCTTATRG--------------------   L   +----------------------------2dgc_A

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updated Fri Sep 13 15:26:39 2024