structure namePAX5(1-149)+ETS-1(331-440)+DNA
(PAIRED BOX PROTEIN PAX5)
referenceWolberger et al. Mol.Cell 8 1267 2001
sourceHOMO SAPIENS
experimentX-ray (resolution=2.25, R-factor=0.231)
structural superfamilyHomeodomain-like;
sequence family'Paired box' domain;
multimeric complexes1k78_BI 1k78_EF 1mdm_AB
redundant complexes1mdm
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNRSHSKISSSSNR

Estimated binding specificities ?

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# IC=8.387 IC/col=0.524 n_of_columns=16 specificity:   
A |  88   0  84  24  84  24   0  24  24  24  24  78  24   0   4   4
C |   0   0   4  24   4  24   5  24  24  24  24   4  24   4   4   6
G |   4  96   4  24   4  24  91  24  24  24  24   6  24   4  78  82
T |   4   0   4  24   4  24   0  24  24  24  24   8  24  88  10   4
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RT--HGSGRGHG--RT----------RTSTKGRGTTLGNT   L   +-----------------------------1u78_A    
                                                 ! 
  NG----STHG--CTSTKG----ITSA--------------   L --3           +-----------------1pdn_C    
                                                 !     +-----1 
  --RT----STVTMCKGDCRGTA------------------   L   +-----2     +-----------------1iv6_A    
                                                       ! 
  --RA----RCET----SAQAKG------------------   L         +-----------------------5lxu_A

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updated Sat Jan 10 04:44:26 2026