structure namePAX5(1-149)+ETS-1(331-440)+DNA
(PAIRED BOX PROTEIN PAX5)
referenceWolberger et al. Mol.Cell 8 1267 2001
sourceHOMO SAPIENS
experimentX-ray (resolution=2.25, R-factor=0.231)
structural superfamilyHomeodomain-like;
sequence family'Paired box' domain;
multimeric complexes1k78_BI 1k78_EF 1mdm_AB
redundant complexes1mdm
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNRSHSKISSSSNR

Estimated binding specificities ?

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# IC=9.487 IC/col=0.593 n_of_columns=16 specificity:   
A |   0  18  86  24  16  24  24  56  24   0  24   1  24   4   0   0
C |  92  72   3  24   5  24  24   9  24  93  24   3  24   3  96   0
G |   1   3   4  24   3  24  24  16  24   3  24   0  24   3   0   0
T |   3   3   3  24  72  24  24  15  24   0  24  92  24  86   0  96
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RT--HGSGRGHG--RT----------RTSTKGRGTTLGNT   L   +-----------------------------1u78_A    
                                                 ! 
  NG----STHG--CTSTKG----ITSA--------------   L --3           +-----------------1pdn_C    
                                                 !     +-----1 
  --RT----STVTMCKGDCRGTA------------------   L   +-----2     +-----------------1iv6_A    
                                                       ! 
  --RA----RCET----SAQAKG------------------   L         +-----------------------5lxu_A

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updated Fri Sep 13 15:44:16 2024