1k78_A : 3D-footprint complex

structure name	PAX5(1-149)+ETS-1(331-440)+DNA (PAIRED BOX PROTEIN PAX5)
reference	Wolberger et al. Mol.Cell 8 1267 2001
source	HOMO SAPIENS
experiment	X-ray (resolution=2.25, R-factor=0.231)
structural superfamily	Homeodomain-like;
sequence family	'Paired box' domain;
multimeric complexes	1k78_BI 1k78_EF 1mdm_AB
redundant complexes	1mdm
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1k78_A interface=11,13,43,44,48,49,65,68,113,115,116,118,119, gvnqlggvfvNgRplpdvvrqrivelahqgvrpcdisrqlrvSHgcvSKilgryyetgsikpgvIggSkpkvatpkvvekiaeykrqnptmfaweirdrllaervcdndtvpSvSSiNRiirtk
interface signature	NRSHSKISSSSNR

Estimated binding specificities ?

readout + contact

# IC=8.228 IC/col=0.514 n_of_columns=16

specificity:

A |   0   8  83  24  22  24  24  24  24   0  24   1  24   5   0   0
C |  87  80   4  24   8  24  24  24  24  91  24   4  24   8  96   5
G |   1   4   5  24   8  24  24  24  24   4  24   0  24   8   0   0
T |   8   4   4  24  58  24  24  24  24   1  24  91  24  75   0  91

scan!

Dendrogram of similar interfaces ?

matrix format

  
  RT--HGSGRGHG--RT----------RTSTKGRGTTLGNT   L   +-----------------------------1u78_A    
                                                 ! 
  NG----STHG--CTSTKG----ITSA--------------   L --3           +-----------------1pdn_C    
                                                 !     +-----1 
  --RT----STVTMCKGDCRGTA------------------   L   +-----2     +-----------------1iv6_A    
                                                       ! 
  --RA----RCET----SAQAKG------------------   L         +-----------------------5lxu_A

home
updated Sun Aug 3 05:41:13 2025