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structure nameCRYSTAL STRUCTURE OF ANDROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO A DIRECT REPEAT RESPONSE ELEMENT
(Androgen receptor)
referenceShaffer et al. Proc.Natl.Acad.Sci.USA 101 4758 2004
sourceRattus norvegicus
experimentX-ray (resolution=3.10, R-factor=?)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes1r4i_AB 8rm6_AB 8rm7_AB
reference complex8rm6_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureHKVKR

Estimated binding specificities ?

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# IC=4.886 IC/col=0.814 n_of_columns=6 specificity:   
A |  79   0  79  73   5  81
C |   5   0  11   5  79   5
G |   5  96   6   5   7   5
T |   7   0   0  13   5   5
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: ANDROGEN RECEPTOR
ACANNNTGTTCTPubMed1r4i_B(1.12e-07)
AGAACAGCAAGTGCTPubMed1r4i_B(2.94e-07)
AGAAGAAAATGTACAPubMed1r4i_B(2.24e-03)
GGTACANNNTGTTCTPubMed1r4i_B(2.94e-07)
GTCACAAAGAGTTCTPubMed1r4i_B(4.19e-04)
TACANNNTGTTCTPubMed1r4i_B(1.48e-07)
TGTCCTPubMed1r4i_B(3.10e-05)
TGTTCTPubMed1r4i_B(5.64e-11)
TGTTGAGAGAGAACAPubMed1r4i_B(2.94e-07)
TTGTTTCAPubMed1r4i_B(7.37e-03)

Dendrogram of similar interfaces ?

matrix format
  
  ----DA--KG--RTRG----   L                   +3cbb_B    
                                           +-1 
  CA--EC--KG--KGRG----   L               +-7 +1cit_A    
                                         ! ! 
  ----EC--KG--RGRG----   L            +-12 +2nll_B    
                                      !  !  
  ----EC--KG--KGRG----   L            !  +-1dsz_B    
                                   +-13  
  --HC----KGVT--RG----   L         !  !  +-3g9m_B    
                                   !  !  !  
  --------KGVT--RG----   L         !  +-11    +1r4o_A    
                                   !     !  +-8 
  ----EA--KG--RTRT--RT   L         !     !  ! +2han_B    
                                   !     +-10  
  --------KGVT--RG----   L      +-14        ! +2c7a_A    
                                !  !        +-9 
  ----EA--KG--KTRG----   L      !  !          ! +2han_A    
                                !  !          +-4 
  --HGECAGKGAAKGRT----   L      !  !            +1lo1_A    
                                !  !  
  --HT----KGVAKTRG----   L      !  !    +1r4i_B    
                             +-15  !  +-2 
  ----EC--KG--KGRG----   L   !  !  +--3 +2a66_A    
                             !  !     ! 
  ----EC--KG--KGRG----   L   !  !     +2ff0_A    
                             !  !  
  ----ET--KGAT--RG----   L -16  !    +1lat_B    
                             !  !  +-5 
  ----EC--KG--RGRGRT--   L   !  +--6 +3e00_D    
                             !     ! 
  ----EC--KG--RGRG----   L   !     +1dsz_A    
                             !  
  ----EC--KGAGKGRG----   L   +-----1hcq_F

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updated Thu Jan 8 19:01:43 2026