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structure nameCRYSTAL STRUCTURE OF HPV6A E2 DNA BINDING DOMAIN BOUND TO AN 18 BASE PAIR DNA TARGET
(Regulatory protein E2)
referenceBrady et al. 'Nucleic 34 3897 2006
sourceHuman papillomavirus type 6a
experimentX-ray (resolution=3.10, R-factor=0.247)
structural superfamilyViral DNA-binding domain;
sequence familyE2 early protein, C terminal;
multimeric complexes2ayb_AB 2ayg_AB
redundant complexes2ayb_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNKCYR

Estimated binding specificities ?

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# IC=4.960 IC/col=0.827 n_of_columns=6 specificity:   
A |   7   0   0   7   7   7
C |  73   0   0   9   7   7
G |   7  96  96   7   9  75
T |   9   0   0  73  73   7
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Dendrogram of similar interfaces ?

matrix format
  
  --NCKGCA--YGRA--------------------------   L                    +----------2ayg_A    
                                                     +------------2 
  KTTGYCNG--RT----------------------------   L       !            !          +1b3t_A    
                                                   +-3            +----------1 
  KGTAYCNG--RT----------------------------   L     ! !                       +5t7x_B    
                                                 +-4 ! 
  --------IC----RCKCIC--EC--RC------------   L   ! ! +-----------------------1zzi_A    
                                               --5 ! 
  ------------------------------RC--------   L   ! +-------------------------2itl_B    
                                                 ! 
  --------------------VG--MG--FG--RTETKTAG   L   +--------------------------2up1_A    
                                               

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updated Fri Sep 13 16:12:30 2024