2n8a_A : 3D-footprint complex

structure name	1H, 13C AND 15N CHEMICAL SHIFT ASSIGNMENTS AND SOLUTION STRUCTURE FOR PARP-1 F1F2 DOMAINS IN COMPLEX WITH A DNA SINGLE-STRAND BREAK (POLY ADP-RIBOSE POLYMERASE 1)
source	HOMO SAPIENS
experiment	NMR
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
sequence family	PolyADPribose polymerase and DNALigase Z;
multimeric complexes	4av1_ABCD
redundant complexes	4av1_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2n8a_A interface=18,41,44,48,49,122,150,151,154, maessdklyrveyaksgRasckkcsesipkdslrmaimvqSpmFdgkVPhwyhfscfwkvghsirhpdvevdgfselrwddqqkvkktaeaggvtgkgqdgigskaektlgdfaaeyaksnRstckgcmekiekgqvrlskkmvdpekpQLgmIdrwyhpgcfvknreelgfrpeysasqlkgfsllatedkealkkqlpgvksegkrkgdevd
interface signature	RSFVPRQLI

Estimated binding specificities ?

contact

# IC=5.614 IC/col=0.125 n_of_columns=45

specificity:

A |   0  24  24  12  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  38  24  12  14   0  24  24  12  24  24  24  24  24  24  24  24  24  24  24  24  24  24  21   9  24   0
C |   0  24  24  12  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  19  24  60  14  96  24  24  12  24  24  24  24  24  24  24  24  24  24  24  24  24  24  33   9  24   0
G |  96  24  24  60  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  19  24  12  16   0  24  24  60  24  24  24  24  24  24  24  24  24  24  24  24  24  24  21  67  24  96
T |   0  24  24  12  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  20  24  12  52   0  24  24  12  24  24  24  24  24  24  24  24  24  24  24  24  24  24  21  11  24   0

scan!

Dendrogram of similar interfaces ?

matrix format

  
  --RGSTFGVTPCRG--QCLCIG   L               +------------2n8a_A    
                                  +--------1 
  ------------RGKG--LCIG       +--2        +------------3odc_B    
                               !  ! 
  --RG--FCVGPG----------     --3  +---------------------3od8_G    
                               ! 
  STRG------------------       +------------------------4av1_A

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updated Tue Dec 17 22:56:34 2024