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structure nameCRYSTAL STRUCTURE ANALYSIS OF TRF2-DBD-DNA COMPLEX
(Telomeric repeat-binding factor 2)
referenceSliverman et al. 'To ? ? ?
sourceHomo sapiens
experimentX-ray (resolution=1.35, R-factor=0.174)
structural superfamilyHomeodomain-like;
sequence familyMyblike DNAbinding domain;
multimeric complexes1w0u_AB 3sjm_AB
redundant complexes1vfc
reference complex1vfc_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKVKDRTR

Estimated binding specificities ?

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# IC=5.432 IC/col=0.905 n_of_columns=6 specificity:   
A |  67  67   0   0   0   9
C |   9   0  96  96  96   9
G |   9  20   0   0   0  11
T |  11   9   0   0   0  67
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: HTRF2
TTAGGGPubMed3sjm_A(1.12e-03), 3sjm_AB(2.07e-04), 1vfc_A(4.63e-03)

Dendrogram of similar interfaces ?

matrix format
  
  RT----------------RCET------SAQAKT----   L                                        +-6qec_A    
                                                               +--------------------3 
  --------DT--------------RGRCTTKT------   L                   !                    +-2o9l_A    
                                                           +---9 
  RA--------------------------YAQTNAAARG   L               !   !          +-----------6wig_A    
                                                           !   +----------6 
  --------------------------RTVAITNAMCRG   L            +-12              +-----------1yrn_A    
                                                        !  !  
  RT----------------STVC----KGDCRG------   L            !  !                        +-1w0t_A    
                                                        !  +------------------------4 
  --------------------KG----RTEC--------   L            !                           +-1h89_C    
                                                        !  
  RA------------------------RCVTCTNAQTRC   L         +-13              +-----------1au7_A    
                                                     !  !              ! 
  RT--------------------------ITQCNAACRG   L         !  !       +------5            +6a8r_A    
                                                     !  !       !      !          +-1 
  RT--------------------------IAQCNAYA--   L         !  !       !      +----------2 +1nk2_P    
                                                     !  !  +----8                 ! 
  RT--------------------------NT--NAITRG   L         !  !  !    !                 +5zjt_B    
                                                  +-14  +-10    ! 
  --------------------------RCVACTNAQA--   L      !  !     !    +------------------7xrc_C    
                                                  !  !     !  
  RT--------------------------IAKGNA----   L      !  !     +-----------------------6m3d_C    
                                                  !  !  
  --LAHAKARA----------------------------       +-15  !  +-------------------------6dta_A    
                                               !  !  +-11  
  ----------LT----NTHG--RT--YTPT--------   L   !  !     !         +---------------6qil_A    
                                               !  !     +---------7 
  ------------YA--KTPTPG----YTRG--------   L -16  !               +---------------4mtd_D    
                                               !  !  
  ------------------RGKG----SGSAQAVC----   L   !  +-----------------------------5no6_N    
                                               !  
  --------------LC----------------------   L   +-----------------------------6nsn_B    
                                             

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updated Thu Sep 12 18:14:42 2024