| structure name | MITF:M-BOX COMPLEX (MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR) |
| reference | Pogenberg et al. 'Genes 26 2647 2012 |
| source | MUS MUSCULUS |
| experiment | X-ray (resolution=2.60, R-factor=0.230) |
| structural superfamily | HLH, helix-loop-helix DNA-binding domain; |
| sequence family | Helixloophelix DNAbinding domain; |
| redundant complexes | 4atk |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | HNIERR |
Estimated binding specificities ?
readout + contact |  |
A | 63 12 0 70 19 63 C | 10 12 96 8 38 10 G | 13 60 0 10 20 10 T | 10 12 0 8 19 13scan! |
Related DNA sequences reported in the literature ?
| site | source | matches (E-value) |
|---|---|---|
| term: M-box | ||
| CATGTG | PubMed | 4ati_B(1.13e-03), 4ati_AB(1.18e-08), 4atk_AB(3.29e-04) |
| GTGTGA | PubMed | 4ati_B(1.13e-03), 4ati_AB(1.02e-02) |
| GTCATGTGCT | PubMed | 4ati_B(2.59e-08), 4ati_AB(7.77e-16), 4atk_AB(1.07e-06), ... (total=4) |
| CACGTG | PubMed | 4ati_AB(3.30e-04), 4atk_AB(1.18e-08), 4atk_B(3.56e-04) |
| term: MITF | ||
| CANNTG | PubMed | 4ati_AB(1.02e-02), 4atk_AB(1.02e-02) |
| CATGTG | PubMed | 4ati_B(1.13e-03), 4ati_AB(1.18e-08), 4atk_AB(3.29e-04) |
| CACCTG | PubMed | 4ati_AB(3.30e-04), 4atk_AB(3.29e-04) |
| TGTGGTC | PubMed | 4ati_B(6.94e-05), 4ati_AB(2.13e-03) |
Dendrogram of similar interfaces ?
matrix format------HGNT--IAEC----RCRT---- L +4ati_B +-1 KT----HGNT----EC----RCRG---- L +-4 +1nkp_A ! ! ------HGNT--LGEC----RCRC---- L +-5 +5i50_B ! ! ------HGNT----EC----RCRG---- L +---------6 +--1nkp_E ! ! ------HGNT--MTEA----RCRG---- L ! ! +1nlw_D ! +----2 ----------HG----IAEC----YCRG L --9 +1am9_A ! --RT----NT--RGEC----RCQT---- ! +-----2ypa_A ! ! ------HGST--ITET----RCRG---- L +--------8 +4h10_A ! +---3 ------HG----ITEC----RCRG---- L +-7 +5nj8_D ! ----QG------VTEC----RCRG---- L +----1an4_A |
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updated Mon Dec 16 22:46:22 2024