structure name | MITF/CLEARBOX STRUCTURE (Microphthalmia-associated transcription factor) |
reference | Pogenberg et al. 'Sci 9 1055 2019 |
source | Mus musculus |
experiment | X-ray (resolution=2.40, R-factor=0.216) |
structural superfamily | HLH, helix-loop-helix DNA-binding domain; |
sequence family | Helixloophelix DNAbinding domain; |
multimeric complexes | 4ati_AB 4atk_AB |
redundant complexes | 4ati_B 4atk_A |
links to other resources | NAKB PDIdb DNAproDB |
protein sequence | |
interface signature | HNER |
Estimated binding specificities ?
contact |
A | 0 13 0 0 57 C | 96 13 0 0 13 G | 0 54 0 96 13 T | 0 16 96 0 13scan! |
Related DNA sequences reported in the literature ?
site | source | matches (E-value) |
---|---|---|
term: M-box | ||
CATGTG | PubMed | 4ati_AB(1.18e-08), 4atk_AB(3.30e-04), 4ati_B(1.14e-03) |
CACGTG | PubMed | 6g1l_A(3.54e-04), 4ati_AB(3.30e-04), 4atk_AB(1.18e-08) |
GTCATGTGCT | PubMed | 4ati_AB(7.77e-16), 4atk_AB(1.07e-06), 4atk_A(7.59e-06), ... (total=4) |
GTGTGA | PubMed | 6g1l_A(3.59e-04), 4ati_AB(1.02e-02), 4ati_B(1.14e-03) |
term: MITF | ||
CANNTG | PubMed | 4ati_AB(1.02e-02), 4atk_AB(1.02e-02) |
CATGTG | PubMed | 4ati_AB(1.18e-08), 4atk_AB(3.30e-04), 4ati_B(1.14e-03) |
CTTGAG | PubMed | 6g1l_A(2.64e-03) |
CACCTG | PubMed | 4ati_AB(3.30e-04), 4atk_AB(3.30e-04) |
TGTGGTC | PubMed | 4ati_AB(2.28e-03), 4atk_A(7.11e-03), 4ati_B(7.00e-05) |
Dendrogram of similar interfaces ?
matrix format------HGNT----EC--RCRG L +-----------------------7d8t_A +---5 ------HGNT--IAEC--YCRG L ! ! +1am9_A ! +-----------------------1 ------HGNT--MTEA--RCRG ! +1nlw_D +-6 --RT----NT--RGEC--RCQT ! ! +------2ypa_A ! ! +-----------3 ------HG------ET--RTRG ! ! ! +------5v0l_A +-7 +--------4 ------RTNT----EC--RCRG L ! ! ! +4h10_B ! ! +-----------------2 NTNGRTECRG--RC-------- L +-8 ! +6od3_F ! ! ! RG----TT--RAEC--RC---- ! ! +-----------------------------1mdy_C --9 ! ------HG------EC--RGRG L ! +-----------------------------4zpk_A ! ------HG----ITEC--RCRG L +-----------------------------5nj8_D |
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updated Fri Sep 13 21:46:54 2024