4glx_A : 3D-footprint complex

3D-footprint cannot reliably estimate the specificity of 'Nucleic acid-binding proteins', as they bind to single-stranded DNA and thus accumulate more base contacts.

Dendrogram of similar interfaces ?

matrix format

structure name	DNA LIGASE A IN COMPLEX WITH INHIBITOR (DNA ligase)
reference	Tidten-Luksch et al. Bioorg.Med.Chem.Lett. 22 6705 2012
source	Escherichia coli
experiment	X-ray (resolution=1.90, R-factor=0.203)
structural superfamily	DNA ligase/mRNA capping enzyme, catalytic domain;RuvA domain 2-like;Nucleic acid-binding proteins;
sequence family	NADdependent DNA ligase adenylation; NADdependent DNA ligase OBfold doma; NADdependent DNA ligase C4 zinc fing; Helixhairpinhelix motif;
redundant complexes	2owo_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4glx_A interface=123,187,188,195,344,346,366,370,371,474, sieqqltelrttlrhheylyhvmdapeipdaeydrlmrelreletkhpelitpdsptqrplaafsqirhevpmlsldnvfdeesflafnkrvqdrtwccelkldglavsilyengvlvsaatRgdgttgeditsnvrtiraiplklhgeniparlevrgevflpqagfekinedarrtggkvfanpRNaaagslRqldpritakrpltffcygvgvleggelpdthlgrllqfkkwglpvsdrvtlcesaeevlafyhkveedrptlgfdidgvvikvnslaqqeqlgfvaraprwavafkfpaqeqmtfvrdvefqvgrtgaitpvarlepvhvagvlvsnaTlHnadeierlglrigdkvvirRagdVIpqvvnvvlserpedtrevvfpthcpvcgsdvervegeavarctgglicgaqrkeslkhfvsrramdvdgmgdkiidqlvekeyvhtpadlfkltagkltgleRmgpksaqnvvnalekakettfarflyalgirevgeataaglaayfgtlealeaasieelqkvpdvgivvashvhnffaeesnrnvisellaegvhwpap

  
  ----------RCNG--RC--------------------HCVGICRA------------------   L                                       +4glx_A    
                                                                                   +-------------------------1 
  ------------NG--RA--------------------HCVCICRA------------------   L             !                         +2owo_A    
                                                                                 +-3 
  --------------------------------------TA------------------------               ! !                     +---6gdr_A    
                                                                               +-4 +---------------------2 
  --------------MG--------------------SA--------------------------             ! !                       +---6rar_I    
                                                                             +-5 ! 
  YALARAKAIA--------FA--------------------------------------------           ! ! +--------------------------2hvr_B    
                                                                           +-6 ! 
  ------------------------------------------------RG--------------         ! ! +----------------------------5tw1_T    
                                                                         +-7 ! 
  ----------------------------------------------NGKGNGRTHGKCECNGNG   L   ! ! +-----------------------------2kn7_A    
                                                                       --8 ! 
  ------------------------------------------------RT--------------       ! +-----------------------------5vi8_T    
                                                                         ! 
  --------------------RTTTKTTTATNTFTNT----------------------------   L   +-----------------------------6bhx_B

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updated Tue Dec 19 08:52:50 2023