4zpk_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2A:ARNT COMPLEX WITH HRE DNA (ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR)
reference	Rastinejad et al. Nature 524 303 2015
source	MUS MUSCULUS
experiment	X-ray (resolution=3.60, R-factor=0.238)
structural superfamily	PYP-like sensor domain PAS domain;HLH, helix-loop-helix DNA-binding domain;
sequence family	PAS fold; Helixloophelix DNAbinding domain;
multimeric complexes	4zpk_AB 4zpr_AB 5sy7_AB 7xi4_AB
redundant complexes	7xi4_A 4zpr 5sy7
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4zpk_A interface=8,12,15,16, erlarenHseiErrRRnkmtayitelsdmvptcsalarkpdkltilrmavshmkslsfltdqelkhlileaadgflfivscetgrvvyvsdsvtpvlnqpqsewfgstlydqvhpddvdklreqlstsrrsficrmrcgtphfvvvhctgyikfclvaigrlqvtefisrhniegiftfvdhrcvatvgyqpqellgknivefchpedqqllrdsfqqvvklkgqvlsvmfrfrsktrewlwmrtssftfqnpysdeieyiictntnv
interface signature	HERR

Estimated binding specificities ?

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# IC=5.051 IC/col=0.842 n_of_columns=6

specificity:

A |   0   7   0   7   7   7
C |  96   7   0   7  73   7
G |   0  75   0  75   7  75
T |   0   7  96   7   9   7

scan!

Dendrogram of similar interfaces ?

matrix format

  
  HG----ECRGRG   L                  +-------------4zpk_A    
                       +------------1 
  HG----ETRTRG   L   +-2            +-------------5v0l_A    
                     ! ! 
  HGNTIAECRCRT   L --3 +--------------------------4ati_B    
                     ! 
  HGNTMTEARCRG   L   +---------------------------1nlw_D

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updated Sun Aug 3 08:45:24 2025