interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2A:ARNT COMPLEX WITH HRE DNA
(ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR)
referenceRastinejad et al. Nature 524 303 2015
sourceMUS MUSCULUS
experimentX-ray (resolution=3.60, R-factor=0.238)
structural superfamilyPYP-like sensor domain PAS domain;HLH, helix-loop-helix DNA-binding domain;
sequence familyPAS fold; Helixloophelix DNAbinding domain;
multimeric complexes4zpk_AB 4zpr_AB 5sy7_AB 7xi4_AB
redundant complexes7xi4_A 4zpr 5sy7
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureHERR

Estimated binding specificities ?

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# IC=4.960 IC/col=0.827 n_of_columns=6 specificity:   
A |   0   7   0   7   7   9
C |  96   9   0   9  75   7
G |   0  73   0  73   7  73
T |   0   7  96   7   7   7
scan!

Dendrogram of similar interfaces ?

matrix format
  
  HG----ECRGRG   L                  +-------------4zpk_A    
                       +------------1 
  HG----ETRTRG   L   +-2            +-------------5v0l_A    
                     ! ! 
  HGNTIAECRCRT   L --3 +--------------------------4ati_B    
                     ! 
  HGNTMTEARCRG   L   +---------------------------1nlw_D    
                   

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updated Fri Sep 13 19:06:01 2024