5a78_B : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE HOMING ENDONUCLEASE I-CVUI IN COMPLEX WITH I- CREI TARGET (C1221) IN THE PRESENCE OF 2 MM MG REVEALING DNA NOT CLEAVED (DNA ENDONUCLEASE I-CVUI)
reference	LopezMendez et al. J.Biol.Chem. 290 28727 2015
source	CHLORELLA VULGARIS
experiment	X-ray (resolution=2.50, R-factor=0.222)
structural superfamily	Homing endonucleases;
sequence family	LAGLIDADG endonuclease;
multimeric complexes	5a72_AB 5a78_AB
redundant complexes	5a72_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5a78_B interface=20,24,26,28,30,31,36,38,44,66,68,69,70,72,74,138, nfhdqlkfawlagfvdadgCinaQiVsReDYllkyQvRvsltvFqsttqhfilldiqkilgcgtvRkRNDgMsEfcvvggtslqttlekllpylqlkraqaklvlqiikklpntkdpsvlmeaalladkvglltdgkKrtilaenvreclkklghvvs
interface signature	CQVRDYQRFRRNDMEK

Estimated binding specificities ?

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# IC=12.496 IC/col=1.041 n_of_columns=12

specificity:

A |   0  84  96   5  79   0   0   0   0   5   7  79
C |  96   0   0   7   5  96   0   0  96   0  11   7
G |   0   7   0   5   5   0  96   0   0  84   5   5
T |   0   5   0  79   7   0   0  96   0   7  73   5

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Dendrogram of similar interfaces ?

matrix format

  
  STITQAKGRG--STNTQTSTATTC------YT--SC--VCDTRGSTKGTG   L         +-----------------------------3mxb_B    
                                                               +-1 
  SALTRGRGNT--KT--STECQGTAHAKA----ST--------KGTC----   L     +-2 +-----------------------------6uwj_A    
                                                             ! ! 
  --MTHTEC--------RGRGQGKG----NT--------ET--KTRG----   L   +-3 +-----------------------------4z1x_A    
                                                           ! ! 
  ST--------SC--LAHTRTTTMT----LT--NC----YA----YA----   L --4 +-----------------------------7rcf_A    
                                                           ! 
  YTSTTC----------YTTC--EC------RG----IA----RGRG----   L   +-----------------------------2qoj_Z

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updated Sun Aug 3 08:46:25 2025