interface graph thumbnail
legend  pdf

structure nameIDENTIFICATION OF A NEW FOXO1 BINDING SITE THAT PRECLUDES CREB BINDING AT THE GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT GENE PROMOTER
(Forkhead box protein O1)
referenceEndrizzi et al. 'J. 198 54 2017
sourceHomo sapiens
experimentX-ray (resolution=2.31, R-factor=0.210)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
multimeric complexes4lg0_AB 5dui_AB 6lbi_CD 6lbi_GH 6lbi_KL
reference complex3co6_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSNSRHNSL

Estimated binding specificities ?

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# IC=3.142 IC/col=0.786 n_of_columns=4 specificity:   
A |   0  54  96  57
C |   0  16   0  13
G |   0  13   0  13
T |  96  13   0  13
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updated Thu Sep 12 21:08:23 2024