interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF A TERNARY FOXO1-ETS1 DNA COMPLEX
(FORKHEAD BOX PROTEIN O1)
referenceGeiger et al. 'To ? ? ?
sourceHOMO SAPIENS
experimentX-ray (resolution=2.19, R-factor=0.197)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
multimeric complexes4lg0_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNSRH

Estimated binding specificities ?

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# IC=5.053 IC/col=0.842 n_of_columns=6 specificity:   
A |   8  16   0   0  96   8
C |   8   8   8   0   0  16
G |   8  64   0   0   0   8
T |  72   8  88  96   0  64
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----------------------NAST--RTHT----ST----------------          +-----------------------------3co7_C    
                                                                  !  
  ----------------------NAST--RGHT----ST----------------   L      !                                +------2uzk_A    
                                                                  !                 +--------------5 
  ----------------------NAST--RGHT----STLT--------------   L      !              +-10              +------7cby_C    
                                                                  !              !  !  
  ------------------------NT--RGCT----NGST--------------   L      !           +-11  +---------------------1if1_B    
                                                                  !           !  !  
  --------RC--------------------------------------------          !        +-12  +------------------------7cow_T    
                                                                  !        !  !  
  ----------------------NAST--RGHT----STLT----------KA--   L      !        !  !                   +-----2c6y_A    
                                                                  !        !  +-------------------4 
  ----------------------NAST--RGHTNT--STLT--------------   L      !        !                      !     +7fj2_B    
                                                               +-16        !                      +-----1 
  --------------------NAST--RGHTNT--STLA----------------   L   !  !        !                            +2hdc_A    
                                                               !  !     +-13  
  ----------------------NGSA--RGHG----SC----------------   L   !  !     !  !                       +---6el8_A    
                                                               !  !     !  !                 +-----3 
  ----KAFA----------------------------------YANAKT--FGMC       !  !     !  !        +--------6     +---3aaf_B    
                                                               !  !     !  !        !        ! 
  --RC--------------------------------------------------       !  !     !  !      +-8        +---------6l9z_S    
                                                               !  !  +-14  !      ! ! 
  ----------------TTHT----KG----------------------------   L   !  !  !  !  +------9 +------------------7b0c_A    
                                                             -17  !  !  !         ! 
  ----------LTNTHG--RT--YTPT------------------------RT--   L   !  !  !  !         !       +-----------6qil_A    
                                                               !  !  !  !         +-------7 
  RT--------LT--HGTA----YTRG----------------------KG--QA       !  +-15  !                 +-----------2efw_A    
                                                               !     !  !  
  ------------------------TT--RTCT----NGKG--------------   L   !     !  +----------------------------7oot_B    
                                                               !     !  
  ----------------------------------------NGAGNGDTQG----       !     !                            +4o3m_A    
                                                               !     +----------------------------2 
  ------------------------RG----YG----------------------       !                                  +1qbj_C    
                                                               !  
  ------------SG--AT----YTRG----------------------------   L   +-----------------------------4rb3_D    
                                                             

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updated Thu Dec 22 20:26:36 2022