interface graph thumbnail
legend  pdf

structure nameHOXB13-MEIS1 HETERODIMER BOUND TO METHYLATED DNA
(HOMEOBOX PROTEIN HOX-B13)
referenceMorgunova et al. Science 356 ? 2017
sourceHOMO SAPIENS
experimentX-ray (resolution=2.54, R-factor=0.230)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes5eg0_AB 5ego_AB 5no6_AN 5no6_BI
redundant complexes5eg0 5no6
reference complex7psx_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRIQN

Estimated binding specificities ?

contactlogo
# IC=3.443 IC/col=0.492 n_of_columns=7 specificity:   
A |  16  24  24   0  96  60  63
C |  16  24  24   0   0  12  10
G |  19  24  24   0   0  12  13
T |  45  24  24  96   0  12  10
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --RA--------------YAQTNAAARG   L                     +-----------6wig_A    
                                               +-------2 
  ----------------RTVAITNAMCRG   L             !       +-----------1yrn_A    
                                     +---------3 
  RCRT--------------NT--NAITRG   L   !         !            +------5zjt_B    
                                   --4         +------------1 
  ----------------RCVACTNAQA--   L   !                      +------7xrc_C    
                                     ! 
  --YTRTTGRGSTATEAST----------   L   +-----------------------------6xg8_A

home
updated Thu Sep 12 21:12:54 2024