interface graph thumbnail
legend  pdf

structure nameHOXB13-MEIS1 HETERODIMER BOUND TO METHYLATED DNA
(HOMEOBOX PROTEIN HOX-B13)
referenceMorgunova et al. Science 356 ? 2017
sourceHOMO SAPIENS
experimentX-ray (resolution=2.54, R-factor=0.230)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes5eg0_AB 5ego_AB 5no6_AN 5no6_BI 8byx_AK 8byx_BJ 8byx_GL
redundant complexes5eg0 5no6
reference complex7psx_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRIQN

Estimated binding specificities ?

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# IC=3.443 IC/col=0.492 n_of_columns=7 specificity:   
A |  10  12   0  96  24  24  45
C |  10  12   0   0  24  24  16
G |  13  12   0   0  24  24  19
T |  63  60  96   0  24  24  16
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --RA--------------YAQTNAAARG   L                     +-----------6wig_A    
                                               +-------2 
  ----------------RTVAITNAMCRG   L             !       +-----------1yrn_A    
                                     +---------3 
  RCRT--------------NT--NAITRG   L   !         !            +------5zjt_B    
                                   --4         +------------1 
  ----------------RCVACTNAQA--   L   !                      +------7xrc_C    
                                     ! 
  --YTRTTGRGSTATEAST----------   L   +-----------------------------6xg8_A

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updated Tue Dec 17 01:36:18 2024