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structure nameSTRUCTURE OF HOXB13 BOUND TO HYDROXYMETHYLATED DNA
(Homeobox protein Hox-B13)
referenceMorgunova et al. 'To ? ? ?
sourceHomo sapiens
experimentX-ray (resolution=2.00, R-factor=0.261)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes5eg0_AB 5ego_AB 5no6_AN 5no6_BI 8byx_AK 8byx_BJ 8byx_GL
redundant complexes5ego_B 8byx_B 5eg0 5no6
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRIQNK

Estimated binding specificities ?

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# IC=7.445 IC/col=0.496 n_of_columns=15 specificity:   
A |   6  24  24  24  24  24  24   6   6  96   0  12  96  24   6
C |   0  24  24  24  24  24  24   0   6   0   0  12   0  24   6
G |  12  24  24  24  24  24  24   6   6   0   0  66   0  24  78
T |  78  24  24  24  24  24  24  84  78   0  96   6   0  24   6
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RT--VTKGNA------KA--   L     +-----------------------------2lkx_A    
                               ! 
  RTQTVAQTNA----------   L     !                            +8osb_E    
                               !             +--------------1 
  RT--IAQCNA----MG----   L   +-5        +----2              +1b72_A    
                             ! !        !    ! 
  ----NCICNARGRG------   L   ! !     +--3    +---------------4xrm_B    
                             ! !     !  ! 
  RC--IAQCNA----YC----   L --6 +-----4  +--------------------3rkq_B    
                             !       ! 
  ----VTCCNA----QA--RT   L   !       +-----------------------8g87_X    
                             ! 
  --------------YCFAKC   L   +-----------------------------6pe2_B    
                           

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updated Wed Dec 18 10:59:05 2024