6joo_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF CORYNEBACTERIUM DIPHTHERIAE CAS9 IN COMPLEX WITH SGRNA AND TARGET DNA
reference	Nishimasu et al. 'Nat 10 1968 2019
experiment	X-ray (resolution=2.90, R-factor=0.222)
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6joo_A interface=49,568,761,765,767,792,793,796, shmkyhvgidvgtfsvglaaievddagmpiktlslvshihdsgldpdeIksavtrlassgiarrtrrlyrrkrrrlqqldkfiqrqgwpvieledysdplypwkvraelaasyiadekergeklsvalrhiarhrgwrnpyakvsslylpdgpsdafkaireeikrasgqpvpetatvgqmvtlceklrgeggvlsarlqqsdyareiqeicrmqeigqelyrkiidvvfaaespkgsassrvgkdplqpgknralkasdafqryriaalignveeknlvfdhlvnltparppthdtnrsivnsriaplvdwwktasaleqhamvkalsnaevddfdspegakvqaffadldddvhakldslhlpvgraaysedtlvrltrrmlsdgytarlqefgiepswtpptprigepvgnpavdrvlktvsrwlesatktwgaperviiehsvawmanelrsrvaqhfashgttvrvyrgsltaegklkffdgvgksrldrrhhaidaaviaftsdyvaetlavrsdaehraawrvwcqkmeklsalltedlrddrvvvmsnvrlrlgngsahKetigklskvklssqlsvsdidkassealwcaltrepgfdpkeglpanperhirvngthvyagdniglfpvsagsialrggyaelgssfhharvykitsgkkpafamlrvytidllpyrnqdlfsvelkpqtmsmrqaekklrdalatgnaeylgwlvvddelvvdtskiatdqvkaveaelgtirrwrvdgfFspsKlRlrplqmskegikkesapelskiidRPgwLpavnklfsdgnvtvvrrdslgrvrlestahlpvtwkvq
interface signature	IKFKRRPL

Estimated binding specificities ?

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# IC=5.807 IC/col=0.968 n_of_columns=6

specificity:

A |  16  13  96   0   0   0
C |  13  13   0  96  96  96
G |  13  13   0   0   0   0
T |  54  57   0   0   0   0

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Dendrogram of similar interfaces ?

matrix format

  
  IC------WAPGYC----------PGRC--NT----KCEGFT------KARGRGPTLT--   L             +----6joo_A    
                                                                     +---------1 
  --RT--RAWCPAWA----RC------------ST----EAEC----KGRA----RGRG--   L   !         +----6wbr_A    
                                                                   --3 
  --KTTT--------LAYA--AGLT--MTTG----KT------SCNT--RGYG--------   L   !    +---------6je3_A    
                                                                     +----2 
  --------YA------YC------LCLG--------------SATT--ST--------SG   L        +---------5x2h_A

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updated Sun Aug 3 11:54:38 2025