6joo_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF CORYNEBACTERIUM DIPHTHERIAE CAS9 IN COMPLEX WITH SGRNA AND TARGET DNA
reference	Nishimasu et al. 'Nat 10 1968 2019
experiment	X-ray (resolution=2.90, R-factor=0.222)
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6joo_A interface=49,568,761,765,767,792,793,796, shmkyhvgidvgtfsvglaaievddagmpiktlslvshihdsgldpdeIksavtrlassgiarrtrrlyrrkrrrlqqldkfiqrqgwpvieledysdplypwkvraelaasyiadekergeklsvalrhiarhrgwrnpyakvsslylpdgpsdafkaireeikrasgqpvpetatvgqmvtlceklrgeggvlsarlqqsdyareiqeicrmqeigqelyrkiidvvfaaespkgsassrvgkdplqpgknralkasdafqryriaalignveeknlvfdhlvnltparppthdtnrsivnsriaplvdwwktasaleqhamvkalsnaevddfdspegakvqaffadldddvhakldslhlpvgraaysedtlvrltrrmlsdgytarlqefgiepswtpptprigepvgnpavdrvlktvsrwlesatktwgaperviiehsvawmanelrsrvaqhfashgttvrvyrgsltaegklkffdgvgksrldrrhhaidaaviaftsdyvaetlavrsdaehraawrvwcqkmeklsalltedlrddrvvvmsnvrlrlgngsahKetigklskvklssqlsvsdidkassealwcaltrepgfdpkeglpanperhirvngthvyagdniglfpvsagsialrggyaelgssfhharvykitsgkkpafamlrvytidllpyrnqdlfsvelkpqtmsmrqaekklrdalatgnaeylgwlvvddelvvdtskiatdqvkaveaelgtirrwrvdgfFspsKlRlrplqmskegikkesapelskiidRPgwLpavnklfsdgnvtvvrrdslgrvrlestahlpvtwkvq
interface signature	IKFKRRPL

Estimated binding specificities ?

readout + contact

# IC=5.766 IC/col=0.961 n_of_columns=6

specificity:

A |   0   0   0   0  54  54
C |   0   0   0   0  13  16
G |  96  96  96   0  16  13
T |   0   0   0  96  13  13

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Dendrogram of similar interfaces ?

matrix format

  
  IC------WAPGYC----------PGRC--NT----KCEGFT------KARGRGPTLT--   L             +----6joo_A    
                                                                     +---------1 
  --RT--RAWCPAWA----RC------------ST----EAEC----KGRA----RGRG--   L   !         +----6wbr_A    
                                                                   --3 
  --KTTT--------LAYA--AGLT--MTTG----KT------SCNT--RGYG--------   L   !    +---------6je3_A    
                                                                     +----2 
  --------YA------YC------LCLG--------------SATT--ST--------SG   L        +---------5x2h_A

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updated Sat Jan 10 10:33:36 2026