6wbr_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF ACECAS9 BOUND WITH GUIDE RNA AND DNA WITH 5'- NNNCC-3' PAM
reference	Das et al. 'Nat 11 6346 2020
experiment	X-ray (resolution=2.91, R-factor=0.226)
redundant complexes	6wc0_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6wbr_A interface=49,852,855,856,896,899, gtvpvtwrlgvdvgersiglaavsyeedkpkeilaavswihdggvgdeRsgasrlalrgmarrarrlrrfrrarlrdldmllselgwtplpdknvspvdawlarkrlaeeyvvdeterrrllgyavshmarhrgwrnpwttikdlknlpqpsdswertreslearysvslepgtvgqwagyllqrapgirlnptqqslsnatafetrlrqedvlwelrciadvqglpedvvsnvidavfcqkrpsvpaerigrdpldpsqlrasraclefqeyrivaavanlrirdgsgsrplsleernavieallaqtersltwsdialeilklpnesdltsvpeedgpsslaysqfapfdetsariaefiaknrrkiptfaqwwqeqdrtsrsdlvaaladnsiagllvhlpdaelealeglalpsgrvaysrltlsgltrvmrddgvdvhnarktcfgvddnwrpplpalheatghpvvdrnlailrkflssatmrwgppqsivvelgsaggyaavalrdrllsygekngvaqvavfrggvtaearrwldisierlfsrvaifaqststkrldrrhhavdavvlttltpgvaktladarsrrvsasteepqspayrqwkescsglgdllistaardsiavaaplrlrptgalheetlrafsehtvgaawkgaelrrivepevyaaflaltdpggrflkvspsedvlpadenrhivlsdrvlgprdrvklfpddrgsirvrggaayiasfhharvfrwgsshspsfallrvsladlavagllrdgvdvftaelppwtpawryasialvkavesgdakqvgwlvpgdeldfgpegvttaagdlsmflkyfperhwvvtgfEddKRinlkpaflsaeqaevlrtersdrpdtlteageilaqffpRcwRatvakvlchpgltvirrtalgqprwrrghlpyswrpwsadpws
interface signature	REKRRR

Estimated binding specificities ?

readout + contact

# IC=5.941 IC/col=0.849 n_of_columns=7

specificity:

A |  96  13  54   0   0   0  13
C |   0  13  13  96  96   0  16
G |   0  20  16   0   0   0  54
T |   0  50  13   0   0  96  13

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Dendrogram of similar interfaces ?

matrix format

  
  --RT--RAWCPAWA--RC------SCATQAST----EAEC----KGRA----RG--RG   L           +------6wbr_A    
                                                                   +-------1 
  IC------WAPGYC----PGRC------------KCEGFT------KARGRGPT--LT   L   !       +------6joo_A    
                                                                 --3 
  ------------------LCLG------------------SATT--ST------KTSG   L   !      +-------5x2h_A    
                                                                   +------2 
  --KTTT--------YA----MTTG--------KTKG----SCNT--RGYG--------   L          +-------6je3_A

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updated Wed Dec 18 06:27:16 2024