interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF ACECAS9 BOUND WITH GUIDE RNA AND DNA WITH 5'- NNNCC-3' PAM
referenceDas et al. 'Nat 11 6346 2020
experimentX-ray (resolution=2.91, R-factor=0.226)
redundant complexes6wc0_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureREKRRR

Estimated binding specificities ?

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# IC=5.957 IC/col=0.851 n_of_columns=7 specificity:   
A |  13  96   0   0  16  48   0
C |  57   0   0   0  13  13   0
G |  13   0  96  96  13  15   0
T |  13   0   0   0  54  20  96
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --RT--RAWCPAWA--RC------SCATQAST----EAEC----KGRA----RG--RG   L           +------6wbr_A    
                                                                   +-------1 
  IC------WAPGYC----PGRC------------KCEGFT------KARGRGPT--LT   L   !       +------6joo_A    
                                                                 --3 
  ------------------LCLG------------------SATT--ST------KTSG   L   !      +-------5x2h_A    
                                                                   +------2 
  --KTTT--------YA----MTTG--------KTKG----SCNT--RGYG--------   L          +-------6je3_A    
                                                                 

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updated Sun Aug 3 13:59:42 2025