6je3_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF NME2CAS9 IN COMPLEX WITH SGRNA AND TARGET DNA (AGGCCC PAM) WITH 5 NT OVERHANG (CRISPR-associated endonuclease Cas9)
reference	Cheng et al. Mol.Cell 76 938 2019
source	Neisseria meningitidis
experiment	X-ray (resolution=2.93, R-factor=0.228)
redundant complexes	6jfu_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6je3_A interface=619,804,806,807,809,811,820, npinyilglaigiasvgwamveideeenpirlidlgvrvferaevpktgdslamarrlarsvrrltrrrahrllrarrllkregvlqaadfdenglikslpntpwqlraaaldrkltplewsavllhlikhrgylsqrkkelgallkgvannahalqtgdfrtpaelalnkfekesghirnqrgdyshtfsrkdlqaelillfekqkefgnphvsgglkegietllmtqrpalsgdavqkmlghctfepaepkaakntytaerfiwltklnnlrileqpltdteratlmdepyrkskltyaqarkllgledtaffkglrygkdnaeastlmemkayhaisralekeglkdkksplnlsselqdeigtafslfktdeditgrlkdrvqpeileallkhisfdkfvqislkalrrivplmeqgkrydeacaeiygdhyteekiylppipadeirnpvvlralsqarkvingvvrrygspaihietarevgksfkdrkeieflcqfvadhilltgkgkrrvfasngqitnllrgendrhhaldavvvactvampweffaqevmirvfgkpdgkpefeeadtpeklrtllaeklssrpeavheyvtplfvsrapnrkmsgahKdtlrsakrfvkhnekisvkrvwlteikladlenmvnykngreielyealkarleayggnakqafdpkdnpfykkggqlvkavrvektqesgvllnkknaytiadngdmvrvdvfckvdkkgknqyfivpiyawqvaenilpdidckgyriddsytfcfslhkydliafqkdekskvefayyincDsSNgRfYlawhdkgsKeqqfristqnlvliqkyqvnelgkeirpcrlkkrppvr
interface signature	KDSNRYK

Estimated binding specificities ?

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# IC=3.142 IC/col=0.786 n_of_columns=4

specificity:

A |   0  13  13   0
C |   0  13  16   0
G |   0  57  54  96
T |  96  13  13   0

scan!

Dendrogram of similar interfaces ?

matrix format

  
  --KTTT----QALAYA--AGLTMTTGNGKTFTKGDGDC--SCNT--RGYGKA------   L       +---------6je3_A    
                                                                   +---2 
  --------YA----YC----LCLG------------TA--SATT--ST------KTSG   L   !   +---------5x2h_A    
                                                                 --3 
  IC--------------------RC--------------FT------KARG--RG--LT   L   !        +----6joo_A    
                                                                   +--------1 
  --RT--RA--------RC--------------------EC----KGRA--------RG   L            +----6wbr_A

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updated Fri Sep 13 22:09:15 2024