interface graph thumbnail
legend  pdf

structure nameHUMAN TCF4 C-TERMINAL BHLH DOMAIN IN COMPLEX WITH 13-BP OLIGONUCLEOTIDE CONTAINING E-BOX SEQUENCE
(Transcription factor 4)
referenceHorton et al. 'Nucleic 47 8375 2019
sourceHomo sapiens
experimentX-ray (resolution=1.49, R-factor=0.222)
structural superfamilyHLH, helix-loop-helix DNA-binding domain;
sequence familyHelixloophelix DNAbinding domain;
multimeric complexes6od3_ABH 6od3_EF 6od3_IJ 6od4_AB 6od5_AB
redundant complexes6od4_H 6od5_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNNRERR

Estimated binding specificities ?

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# IC=4.250 IC/col=0.708 n_of_columns=6 specificity:   
A |  12  24   0  96   0  12
C |  12  24  84   0  96  12
G |  12  24   0   0   0  60
T |  60  24  12   0   0  12
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updated Tue Dec 19 13:56:33 2023