6pax_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE HUMAN PAX-6 PAIRED DOMAIN-DNA COMPLEX REVEALS A GENERAL MODEL FOR PAX PROTEIN-DNA INTERACTIONS (HOMEOBOX PROTEIN PAX-6)
reference	Epstein et al. 'Genes 13 1263 1999
source	Homo sapiens
experiment	X-ray (resolution=2.50, R-factor=0.233)
structural superfamily	Homeodomain-like;
sequence family	'Paired box' domain;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6pax_A interface=14,16,46,47,49,51,52,68,71,74,116,117,118,119,121,122,125, shsgvnqlggvfvNgRplpdstrqrivelahsgarpcdisrilqvSNgCvSKilgryyatgsirpraIggSkpRvatpevvskiaqykqecpsifaweirdrllsegvctndnipSVSSiNRvlRnlasekqq
interface signature	NRSNCSKISRSVSSNRR

Estimated binding specificities ?

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# IC=7.222 IC/col=0.602 n_of_columns=12

specificity:

A |  12   5  86   5  24  24  24   5  24   0   0   0
C |   5  80   5  80  24  24  24  12  24  96   5   0
G |  74   6   5   5  24  24  24   5  24   0  85   0
T |   5   5   0   6  24  24  24  74  24   0   6  96

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Dendrogram of similar interfaces ?

matrix format

  
  --RC----IAQCNAYC--   L                             +---3rkq_B    
                           +-------------------------2 
  ----RT--NT--NAIARG   L   !                         +---4cyc_B    
                         --3 
  --RT--QTVAQTNA----   L   !                            +8osb_E    
                           +----------------------------1 
  RT------IAQCNAMG--   L                                +1b72_A

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updated Tue Jun 30 00:18:26 2026