interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE HUMAN PAX-6 PAIRED DOMAIN-DNA COMPLEX REVEALS A GENERAL MODEL FOR PAX PROTEIN-DNA INTERACTIONS
(HOMEOBOX PROTEIN PAX-6)
referenceEpstein et al. 'Genes 13 1263 1999
sourceHomo sapiens
experimentX-ray (resolution=2.50, R-factor=0.233)
structural superfamilyHomeodomain-like;
sequence family'Paired box' domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNRSNCSKISRSVSSNRR

Estimated binding specificities ?

readout + contactlogo
# IC=8.921 IC/col=0.743 n_of_columns=12 specificity:   
A |  96   2   0  16  59  24  24  32   3   4   1   4
C |   0  92   2  59   0  24  24  61   2   2   0  71
G |   0   2  93  12  12  24  24   1  91   2  93   2
T |   0   0   1   9  25  24  24   2   0  88   2  19
scan!

Dendrogram of similar interfaces ?

matrix format
  
  HGSGRGHGRT--RT--STKGRGTTLGNT--------   L           +-----------------------------1u78_A    
                                                   +-1 
  --------------RT----------ITQCNAACRG   L       +-2 +-----------------------------6a8r_A    
                                                 ! ! 
  --------------------------VAQTNA----   L     +-3 +-----------------------------1fjl_B    
                                               ! ! 
  ----------KG--RT----------IAQCNAYA--   L   +-4 +-----------------------------1nk2_P    
                                             ! ! 
  ------------------------RTVAITNAMCRG   L --5 +-----------------------------1yrn_A    
                                             ! 
  --------------------------VAQTNA----   L   +-----------------------------5hod_A    
                                           

home
updated Fri Sep 13 22:55:36 2024